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    Hi Customer I'm going to say this directly, if you want to do what's best for your little one, I would take him into your vet for them to evaluate. By checking him over, they can make sure that the best course of therapy is chosen to give your little one the best chance of recovering from this. If it truly is an URI, then they can best dose the antibiotic that they feel will work (Bactrim would definitely be a choice as well as a flourquinolone type drug). There could be dental issues or other oral issues that might be masking as an URI. In all honesty, you can get Bactrim online at Doctor's Foster and Smith. But the dosing for little one like a guinea pig is very, very, very difficult. I would absolutely recommend the exam by your vet so the right antibiotic and dose can be chosen based on the situation. ​An upper respiratory infection (URI) is a common illness for guinea pigs. When accompanied by nose goop, crusty eyes, and labored breathing, it's definitely cause for concern. But too many sneezes can signify something more sinister. When caught early, antibiotics can usually knock it out. However, because guinea pigs are so skilled at hiding illness, sometimes we don't notice until things have gone downhill. A 14-day course of Baytril is far from the only option for treating stubborn respiratory infections. Once the respiratory infection is well set in, treatment becomes more challenging. , isolate your guinea pig from her pals so the whole crew doesn't get sick. A URI can turn into pneumonia between the time your trusted exotic vet closes at 5 p.m. Putting your guinea pig in the bathroom while you take a steamy shower can help her breathe a little easier. An upper respiratory infection won't get better without antibiotics.

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