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  1. viking1500 Well-Known Member

    Viagra chemistry


    When couples talk about having "chemistry" together, who knew it was such an accurate description? The brain sends signals to NANC cells in the artery. Nitric oxide acts as a signaling molecule and stimulates an enzyme called guanylate cyclase in nearby cells. The guanylate cyclase converts a chemical called GTP into another chemical called c GMP. c GMP causes muscles in the walls of the arteries to relax. Meanwhile, PDE is decomposing the c GMP and turning it back into GTP. There is a cycle -- guanylate cyclase turns GTP into c GMP, and PDE turns c GMP into GTP. ­c GMP is produced as long as the brain is sending messages down the nerve fibers in the artery, which generate nitric oxide and keep the cycle going. When the brain stops sending the signal, all of the c GMP goes away because PDE is deactivating it. This way, the brain can turn valves on and off whenever it wants to. When the brain gets aroused, it sends a signal to the penis. metoprolol heart block To better understand its function, consider that an enzyme is a specially folded protein that can speed up a chemical reaction. (For example, the article How Cells Work describes the maltase enzyme.) In the accompanying diagram, you see that maltose is made of two glucose molecules bonded together (1). The maltase enzyme is a protein perfectly shaped to accept a maltose molecule and break the bond (2). A single maltase enzyme can break more than 1,000 maltose bonds per second, and will only accept maltose molecules. PDE5 is an enzyme that accepts c GMP and breaks it down. Pfizer needed a chemical that would gum up PDE5 and keep it from doing its job. The chemical that Pfizer discovered is called sildenafil citrate. It fits right into the PDE5 enzyme and disables it.

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    Chemistry. Chemical Compounds.­The first problem comes because Viagra happens to have a spillover effect. It blocks PDE5, but it also has an effect on PDE6. cheap viagra generic pills Earlier, we talked about the enzyme PDE. To better understand its function, consider that an enzyme is a specially folded protein that can speed up a chemical. Viagra. Researchers in Ian Osterloh's lab at Pfizer stopped work on developing sildenafil citrate as a therapy for chest pain in men in 1992 following unpromising.

    The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart. Researchers in Ian Osterloh's lab at Pfizer stopped work on developing sildenafil citrate as a therapy for chest pain in men in 1992 following unpromising results in a Phase I angina study. They noticed, however, that some of the men taking 50- and 75-mg doses in the trial reported an increased tendency to get erections, suggesting a surprise "act two" for sildenafil. "Gradually, a consensus grew that research should shift from angina to the drug's erectile angle, and the rest is, as they say, history," says Daniel J. Viagra was approved by the Food & Drug Administration in 1998 as a therapy for erectile dysfunction (ED), a term for impotence that surfaced in the 1990s. The drug rose swiftly to blockbuster status, achieving sales of $1 billion in its first full year on the market. Physically, Viagra works by inhibiting an enzyme called phosphodiesterase type 5 (PDE5), which normally cleaves cyclic guanosine monophosphate (c GMP), a compound that promotes smooth-muscle relaxation in the corpus cavernosum, thus enhancing blood flow. This enhances the effect of nitric oxide, a chemical released in response to sexual stimulation. Nitric oxide activates guanylate cyclase, an enzyme that boosts levels of c GMP. and Icos, and Bayer Pharmaceutical's Levitra are also PDE5 inhibitors.

    Viagra chemistry

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    Viagra is generally prescribed for men with erectile dysfunction. Explore the article and get some interesting information on the history, background & origin of Viagra. buy colchicine online uk Save on brand name VIAGRA® sildenafil citrate for up to 12 months. VIAGRA® can help treat the symptoms of ED. Sildenafil, sold as the brand name Viagra among others, is a medication used to treat erectile. "Chemists plan to sell Viagra on the internet". Daily Record.

     
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