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    Harry Lever, a cardiologist at the Cleveland Clinic, has been warning nearly anyone who would listen of his growing suspicions about generic versions of a widely used heart drug, Toprol XL. “The doctors in this country need to know what’s going on, because we’re ultimately writing the prescriptions and we’re responsible,” Dr. “There’s been this assumption that one generic is the same as another. Patient after patient, he said, would visit his office complaining of chest pains or other symptoms after switching from the brand-name version, made by Astra Zeneca, to a generic product, often one made in India. Reddy’s Laboratories, have announced recalls over the last two months totaling more than 100,000 bottles because their products were not dissolving properly — therefore probably not working as they should. is taking a closer look at the quality of generic drugs, which now account for more than 80 percent of prescriptions in the United States. Not in this case.”Representatives for Wockhardt and Dr. When he switched them back to the brand — or to another generic — the symptoms disappeared, he said. Lever wrote a letter outlining his concerns to the Food and Drug Administration in 2012, and this year, he traveled to Washington to try to get the attention of Congress. Lever could not prove that the generic drugs were to blame. The drug is a beta blocker that treats high blood pressure and heart ailments. The number of recalled bottles is relatively small compared with the 38 million prescriptions for the drug, known generically as metoprolol succinate, that were filled in the United States in 2013, according to the research firm IMS Health. Reddy’s did not return calls or reply to an email seeking comment. thoroughly vetted generic drugs and a “bioequivalence designation assures U. patients and caregivers that generic medicines, regardless of the geographic location of origin, are the same medicine with the same active ingredients as the brand but at a lower cost.”Mr. “You see enough people and you get a feel, but it’s anecdotes,” he said in an interview Monday. The recalls are the latest in a string of recent problems involving generic drugs, especially those made in India. The recalls are considered Class II, meaning they may cause temporary health problems but are unlikely to pose an immediate safety threat. Ralph Neas, the president of the Generic Pharmaceutical Association, the industry trade group, said the F. Neas also noted that generic companies supported a 2012 bill that increased funding — through industry-generated user fees — to scrutinize generic manufacturing, especially overseas. undertook a “multidisciplinary investigation” of the efficacy and quality of each of the versions of metoprolol succinate available in the United States. Wockhardt, for example, is now banned from exporting drugs to the United States that were manufactured in two Indian plants where F. Generic manufacturers have repeatedly stumbled in their attempts to copy Toprol XL, which lost its patent protection in 2006. The agency concluded then that all of the versions, including those made by Wockhardt and Dr. Earlier this year the agency put a call out to researchers to investigate the efficacy of generic versions of metoprolol succinate, which is best known by Astra Zeneca’s brand name, Toprol XLEven as the agency has stepped up its scrutiny of generics, however, it has maintained its long-held position that generic drugs are generally as safe and effective as the brand-name versions. Lever and other critics of generic drugs say the agency needs to be more frank about the potential downsides to generics. The agency is also more closely studying all extended-release products, like the two recalled products, which are more technically difficult to make. Metoprolol Reviews Everyday Health order accutane from canada Новости Счетчики газа, Счетчики воды - ООО "Факториал-Стандарт" Recall Metoprolol succinate extended-release tablets - PharmPix
     
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