—I read with interest the article by Johnson  suggesting a more prominent role for doxycycline in empiric therapy for community-acquired pneumonia (CAP).  described an in vitro susceptibility survey that compared tetracycline with doxycycline against bacterial pathogens causing CAP. The survey emphasized the relative lack of susceptibility of to doxycycline, potentially limiting its usefulness for empiric treatment of CAP. Some key points about doxycycline were not included in either article.  argue the doxycycline is not much better than tetracycline in terms of pneumococcal resistance. Although the susceptibility breakpoint against is the same for tetracycline and doxycycline (i.e., ⩾2 µg/m L), the pharmacokinetics/pharmacodynamics of doxycycline are very different from those of tetracycline. Interpretation of susceptibility breakpoints should be based on achievable serum concentrations. Serum concentrations of ⩾2 µg/m L are difficult to achieve with tetracycline (the peak serum concentration after a 500-mg dose is ∼1.5 µg/m L) but are easily achieved with doxycycline (the peak serum concentration after a 100-mg intravenous or oral dose is ∼4 µg/m L, and it is ∼8 µg/m L after a 200-mg intravenous or oral dose). It is not appreciated by many clinicians that doxycycline is 5 times more lipid-soluble than tetracycline and has a much longer half-life (8 h vs. Accordingly, when doxycycline is used for treatment of CAP, dosing should be initiated using a loading regimen, either intravenously or orally, depending upon the severity of the pneumonia. tamoxifen side effects men Community-acquired pneumonia (CAP) is one the most common infectious diseases addressed by clinicians. It is a major health problem in the United States and is an important cause of mortality and morbidity worldwide. CAP is defined as pneumonia acquired outside a hospital or long-term care facility. It occurs within 48 hours of hospital admission or in a patient presenting with pneumonia who does not have any of the characteristics of healthcare-associated pneumonia (ie, hospitalized in an acute care hospital for 2 or more days within 90 days of infection; resided in a nursing home or long-term care facility; received recent intravenous antibiotic therapy, chemotherapy, or wound care within the past 30 days of the current infection; or attend a hospital or hemodialysis clinic). (all strains penicillin-resistant) and account for approximately 85% of CAP cases. CAP is usually acquired via inhalation or aspiration of a pulmonary pathogen into a lung segment or lobe. Less commonly, CAP results from secondary bacteremia from a distant source, such as Atypical pathogen CAP manifests a variety of pulmonary and extrapulmonary findings (eg, CAP plus diarrhea). Cipro el salvador Metformin 750 mg side effects Community-acquired pneumonia CAP is one the most common infectious diseases addressed by clinicians. Doxycycline 100 mg PO bid. propranolol hypothyroidism The worst kind of pneumonia, high risk for multidrugresistant. hospital-acquired pneumonia, or ventilator-associated pneumonia VAP, Zosyn. Site of action. Antimicrobial Action. Like other tetracyclines doxycycline is bacteriostatic with action against a varied range of aerobic and anaerobic gram-positive and gram-negative bacteria. Doxycycline Capsules are used in the treatment of a variety of infections caused by susceptible strains of Gram-positive and Gram-negative bacteria and certain other micro-organisms. Escherichia coli, Streptococcus faecalis and other organisms. 1) Respiratory tract infections: Pneumonia and other lower tract respiratory tract infections due to susceptible strains of Streptococcus pneumoniae, Haemophilia influenzae, Klebsiella pneumoniae and other organisms. 3) Sexually transmitted diseases: Infections due to Chlamydia trachomatis including uncomplicated urethral, endocervical or rectal infections. 2) Urinary tract infections: Infections caused by susceptible strains of Klebsiella species, Enterobacter species. Non-gonococcal, urethritis caused by Ureaplasma urealyticum. Chancroid infections due to alymmatobacterium granulomatis. Alternative drug in the treatment of gonorrhoea and syphilis. 4) Dermatological infections: Acne vulgaris when antibiotic therapy is considered necessary. Since doxycycline is a member of the tetracycline series of antibiotics, it may be expected to be useful in the treatment of infections which respond to other tetracyclines, such as: 1) Ophthalmic infections: Due to susceptible strains of gonococci, staphylococci and Haemophilus influenzae. Doxycycline Capsules are indicated in the treatment of trachoma, although the infectious agent is not always eliminated, as judged by immunofluorescence. The mainstay of drug therapy for bacterial pneumonia is antibiotic treatment. The choice of agent is based on the severity of the patient's illness, host factors (eg, comorbidity, age), and the presumed causative agent. Although intravenous (IV) penicillin G is currently not favored, doses in the range of 20-24 million U/d result in serum levels that exceed minimum inhibitory concentration (MIC) levels of most resistant pneumococci. The role of glucocorticoids in acute bacterial pneumonia has yet to be clearly elucidated. Classic teaching warns that the use of glucocorticoids in infection may impair the immune response. However, findings demonstrate that local pulmonary inflammation may be reduced with systemic glucocorticoids. In a 2015 meta-analysis of 13 randomized controlled trials evaluating the use of systemic corticosteroids in patients hospitalized for CAP,it was found with high certainty that systemic corticosteroid steroid treatment reduced the duration of hospitalization by approximately 1 day and had a 5% absolute reduction in risk for mechanical ventilation. Doxycycline for pneumonia Bacterial Pneumonia Medication Antibiotics, Glucocorticoids., A Look at Antibiotics to Treat Pneumonia - Pharmacy Times Norvasc swelling how to treat Buy clomid and nolvadex pct User Reviews for Doxycycline systemic. Also known as Acticlate, Adoxa, Alodox, Avidoxy, Doryx, Mondoxyne NL, Monodox, Morgidox, Oracea, Oraxyl, Targadox, Vibramycin The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in. Doxycycline systemic User Reviews for Acne at Antibiotic Drugs, Information, Description on Doxycycline. Pneumonia Atypical Walking Pneumonia Management and. Reviews and ratings for doxycycline when used in the treatment of pneumonia. 36 reviews submitted. cheap generic xenical BACKGROUND Community-acquired pneumonia CAP affects 5-10 million. for treatment of CAP in general medical wards and doxycycline monotherapy for. User Reviews for Doxycycline to treat Bacterial Infection. Also known as Acticlate, Adoxa, Alodox, Avidoxy, Doryx, Mondoxyne NL, Monodox, Morgidox, Oracea, Oraxyl, Targadox, Vibramycin The following information is NOT intended to endorse drugs or recommend therapy.