Drug Uses Accutane is used for treating severe acne in patients who do not respond to other medicines. It may also be used for other conditions as determined by your doctor. Take it with a full glass of water, milk, or other nonalcoholic liquid. Depending on your reaction to Accutane, your doctor may need to adjust the dosage upward or downward. How to use Take Accutane two times a day with a meal, unless your doctor tells you otherwise. If you respond quickly and very well, your doctor may take you off Accutane even before the 15 or 20 weeks are up. After you finish taking Accutane, there should be at least a 2-month "rest period" during which you are off the drug. This is because your acne may continue to get better even though you are no longer taking the medication. Once the 2 months are up, if your acne is still severe, your doctor may want to give you a second course of Accutane. If you are still growing, your doctor may recommend a longer "rest period." 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