It comes as an oral tablet, an orally disintegrating tablet, and an oral solution. It also comes as an injection that’s only given by a healthcare provider. Risperidone oral tablet is available as the brand-name drug Risperdal. Generic drugs usually cost less than the brand-name version. In some cases, the brand-name drug and the generic version may be available in different forms and strengths. Risperidone is used to treat the symptoms of several psychiatric conditions. These include: Risperidone may be used as part of a combination therapy. This means you may need to take it with other medications. Not approved for dementia-related psychosis, because of increased risk of cardiovascular or infectious related deaths (see Black Box Warnings)Risk of orthostatic hypotension higher in elderly; monitoring of renal function and orthostatic blood pressure may be necessary; for titrating to target dose, twice-daily regimen should be used and dosage maintained for 2-3 days before change is made to once-daily dose regimen 1.5 mg q12hr should occur at intervals ≥1 week IM: 12.5-25 mg injected into deltoid or gluteal muscle every 2 weeks; dosage should not be adjusted more frequently than every 4 weeks Recommended to establish tolerability of PO risperidone before initiating treatment with IM risperidone Somnolence (40-45%) Insomnia (26-30%) Agitation (20-25%) Anxiety (10-15%) Headache (10-15%) Rhinitis (10-15%) Fatigue (18-31%) Parkinsonism (28-62%) Akathisia (5-11%) Increased appetite (4-44%) Vomiting (10-20%) Drooling ( Diabetes mellitus Hyperthermia Hypoglycemia Hypothermia Myelosuppression Neuroleptic malignant syndrome (NMS) Priapism Prolonged QT interval Tardive dyskinesia Thrombotic thrombocytopenic purpura (TTP) Sleep apnea syndrome Urinary retention Blood and lymphatic system disorders: Anemia, granulocytopenia Cardiac disorders: Tachycardia, sinus bradycardia, sinus tachycardia, atrioventricular block first degree, bundle branch block left, bundle branch block right, atrioventricular block Ear and labyrinth disorders: Ear pain, tinnitus Eye Disorders: Vision blurred, oculogyration, ocular hyperemia, eye discharge, conjunctivitis, eye rolling, eyelid edema, eye swelling, eyelid margin crusting, dry eye, lacrimation increased, photophobia, glaucoma, visual acuity reduced Gastrointestinal disorders: Dysphagia, fecaloma, fecal incontinence, gastritis, lip swelling, cheilitis, aptyalism General disorders: Thirst, gait disturbance, chest pain, influenza-like illness, pitting edema, edema, chills, sluggishness, malaise, face edema, discomfort, generalized edema, drug withdrawal syndrome, peripheral coldness, feeling abnormal Immune system disorders: Drug hypersensitivity Infections and infestations: Nasopharyngitis, upper respiratory tract infection, sinusitis, urinary tract infection, pneumonia, influenza, ear infection, viral infection, pharyngitis, tonsillitis, bronchitis, eye infection, localized infection, cystitis, cellulitis, otitis media, onychomycosis, acarodermatitis, bronchopneumonia, respiratory tract infection, tracheobronchitis, otitis media chronic Investigations: Body temperature increased, alanine aminotransferase increased, heart rate increased, eosinophil count increased, white blood cell count decreased, hemoglobin decreased, blood creatine phosphokinase increased, hematocrit decreased, body temperature decreased, blood pressure decreased, transaminases increased Metabolism and nutrition disorders: Polydipsia, anorexia Musculoskeletal, connective tissue, and bone disorders: Joint swelling, musculoskeletal chest pain, posture abnormal, myalgia, neck pain, muscular weakness, muscle rigidity, muscle contracture, rhabdomyolysis Nervous system disorders: Dizziness postural, disturbance in attention, unresponsive to stimuli, depressed level of consciousness, movement disorder, hypokinesia, bradykinesia, transient ischemic attack, coordination abnormal, cerebrovascular accident, masked facies, speech disorder, syncope, loss of consciousness, muscle contractions involuntary, Parkinson disease, tongue paralysis, akinesia, cerebral ischemia, cerebrovascular disorder, neuroleptic malignant syndrome, diabetic coma, head titubation Psychiatric disorders: Agitation, blunted affect, confusional state, middle insomnia, nervousness, sleep disorder, listlessness Renal and urinary disorders: Enuresis, dysuria, pollakiuria, urinary incontinence Reproductive system and breast disorders: Vaginal discharge, menstrual disorder, retrograde ejaculation, sexual dysfunction Falls Alopecia, anaphylactic reaction, angioedema, atrial fibrillation, cardiopulmonary arrest, diabetic ketoacidosis in patients with impaired glucose metabolism, dysgeusia, hypoglycemia, hypothermia, ileus, inappropriate antidiuretic hormone secretion, intestinal obstruction, jaundice, mania, pancreatitis, pituitary adenoma, precocious puberty, pulmonary embolism, QT prolongation, sleep apnea syndrome, sudden death, thrombocytopenia, thrombotic thrombocytopenic purpura, urinary retention, and water intoxication Increased incidence of cerebrovascular disease reported; may alter cardiac conduction; life threatening arrhythmias reported with therapeutic doses of antipsychotics May cause anticholinergic effects including blurred vision, urinary retention, agitation, confusion, blurred vision, and xerostomia Use with caution in patients with history of seizures, Parkinson disease, Lewy body dementia, cardiovascular disease, hypovolemia, dehydration Leukopenia/neutropenia and agranulocytosis reported; possible risk factors for leukopenia/neutropenia include preexisting low white blood cell (WBC) count and history of drug-induced leukopenia/neutropenia If patient has history of clinically significant low WBC count or drug-induced leukopenia/neutropenia, monitor complete blood count (CBC) frequently during first few months of therapy; discontinue drug at first sign of clinically significant WBC decline There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to atypical antipsychotics, including risperidone, during pregnancy Healthcare professionals are encouraged to register patients by contacting the National Pregnancy Registry for Atypical Antipsychotics at 1-866-961-2388 or online at programs/ pregnancyregistry/ Limited data from published literature reports the presence of risperidone and its metabolite, 9- hydroxyrisperidone, in human breast milk at relative infant dose ranging between 2.3 and 4.7% of the maternal weight-adjusted dosage Reports of sedation, failure to thrive, jitteriness, and extrapyramidal symptoms (tremors and abnormal muscle movements) in breastfed infants exposed to risperidone Consider the developmental and health benefits of breastfeeding along with the mother’s clinical need for the drug, and any potential adverse effects on the breastfed infant from the drug or from the underlying maternal condition Improves negative symptoms of psychoses and reduces incidence of EPS Has high affinity for serotonin type 2 (5-HT2) receptors; binds to dopamine D2 receptors with 20 times lower affinity than that for 5-HT2 receptors; antagonizes alpha1-adrenergic, alpha2-adrenergic, and histaminergic receptors; has moderate affinity for serotonin type 1 (5-HT1C, 5-HT1D, 5-HT1A) receptors; has weak affinity for dopamine D1 receptors; has no affinity for muscarinic, beta1-adrenergic, and beta2-adrenergic receptors Peak plasma time, steady-state: 4-6 hr (SC) Peak plasma concentration: 6.33-10.9 ng/m L (risperidone, 9-hydroxyrisperidone) AUC: 2262-3891 ng·hr/m L Bioavailability: 70% Peak plasma time: Extensive metabolizers, 3 hr; poor metabolizers, 17 hr Half-life: Extensive metabolizers, 3 hr (parent and metabolite combined); poor metabolizers, 20 hr (parent and metabolite combined); prolonged in renal impairment; free fraction increase in hepatic disease Half-life: 8-9 days (9-hydroxyrisperidone and total active moiety) Excretion: Urine (70%), feces (14%) Visually inspect for particulate matter and discoloration prior to administration Hold powder syringe upright tap the barrel of the syringe to unpack the powder Remove caps from both powder syringe and diluent syringe Connect both syringes; do not over tighten Keep your fingers off the plunger to avoid drug spillage For abdominal SC injection, only Do not administer by any other route To be administered by a healthcare professional only Choose an injection site on the abdomen with adequate SC tissue that has no skin conditions (eg, nodules, lesions, excessive pigment); recommended patient be in the supine position; rotate injection sites (refer to prescribing information) Allow package to come to room temperature for at least 15 minutes prior to preparation Only prepare medication when you are ready to administer the dose As a universal precaution, always wear gloves Remove dose pack from refrigerator; allow to sit at room temperature at least 30 minutes before reconstituting; do not warm any other way Remove vial cap; connect vial adapter Keep vial vertical to prevent leakage Hold base of vial and pull up on the sterile blister to remove; do not shake; do not touch exposed luer opening on vial adapter; this will result in contamination Remove cap from liquid cap; connect liquid syringe to the vial adapter Do not hold glass syringe barrel; may cause the white collar to loose or detach Inject diluent, suspend microspheres in diluent Continuing to hold down the plunger rod, shake vigorously for at least 10 seconds, as shown; check the suspension Microspheres will be visible in the liquid; immediately proceed to the next step so suspension does not settle Immediately inject entire contents of syringe IM into the gluteal or deltoid muscle of the patient Gluteal injection should be made into the upper-outer quadrant of the gluteal area Do not IV administer The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Metoprolol monograph Antabuse and pregnancy Prednisone liver disease Prednisone 7 day pack dosage Eventual maintenance dose schedule is BID. 1/3 in am, 2/3 in p.m. olanzapine. 5-10 mg QD. 5 mg/week. 10 – 20 mg/day. HS risperidone. 0.5 - 1 mg QD. Medscape - Schizophrenia, bipolar disorder-specific dosing for Risperdal, Risperdal Consta risperidone, frequency-based adverse effects, comprehensive. Nov 7, 2009. An expert consensus group has published charts of equivalent doses. 5B used the same approach to define equivalent doses of risperidone. *The recommended maintenance dose for the treatment of schizophrenia is 117 mg. Some patients may benefit from lower or higher maintenance doses within the additional available strengths (39 mg, 78 mg, 156 mg, and 234 mg). In some patients, slower titration may be appropriate. May increase the dose at intervals of 24 hours or greater, in increments of 1 to 2 mg per day, as tolerated, to a recommended dose of 4 to 8 mg per day. Efficacy has been demonstrated in a range of 4 mg to 16 mg per day. However, doses above 6 mg per day for twice daily dosing were not demonstrated to be more efficacious than lower doses, were associated with more extrapyramidal symptoms and other adverse effects, and are generally not recommended. In a single study supporting once-daily dosing, the efficacy results were generally stronger for 8 mg than for 4 mg. The safety of doses above 16 mg per day has not been evaluated in clinical trials The initial dose is 0.5 mg once daily, administered as a single-daily dose in the morning or evening. The dose may be adjusted at intervals of 24 hours or greater, in increments of 0.5 mg or 1 mg per day, as tolerated, to a recommended dose of 3 mg per day. Risperdal dosage chart INVEGA SUSTENNA® Dosing Maintenance HCP, Risperdal, Risperdal Consta risperidone dosing, indications. Diflucan or monistatValacyclovir 2 gramsPropranolol trade name Risperidone should be administered on a once daily schedule, starting with 2 mg risperidone. Dosage adjustments, if indicated, should occur at intervals of not. Risperidone 1mg/ml Oral Solution - Summary of Product. - eMC. Antipsychotic Dose Equivalents and Dose-Years A Standardized.. Safer Prescribing of Antipsychotics Guideline - San Francisco.. The nighttime once-daily risperidone dosage was well tolerated by patients. chart review of patients who had been on once-daily risperidone treatment for an. Risperidone oral tablet is a prescription drug used to treat schizophrenia, bipolar I disorder, and irritability. Learn about side effects, warnings, dosage, and more. RISPERDAL® is an atypical antipsychotic agent indicated for • Treatment of. mg twice daily, followed by increases in dose in increments of no more than 0.5.