Hydroxychloroquine mechanism of action sle

Discussion in 'Pharmacy Northwest Canada' started by hongerius, 27-Feb-2020.

  1. Tenkan XenForo Moderator

    Hydroxychloroquine mechanism of action sle


    Derm Net NZ Medical Editor: Dr Delwyn Dyall-Smith, Dermatologist, Wagga Wagga, NSW, Australia. However, following an identical dose of hydroxychloroquine and chloroquine, tissue levels of chloroquine are 2.5 times those of hydroxychloroquine. Derm Net NZ Editor in Chief: Adjunct Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand. Hydroxychloroquine is preferred due to its safer profile.

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    Medscape - Indication-specific dosing for Plaquenil hydroxychloroquine sulfate, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. The understanding that one mechanism of action of hydroxychloroquine is the antagonism of TLR7 and TLR9 signaling is also intriguing, given the postulated roles of IFN-α in endothelial dysfunction and abnormal vascular repair. 177 Prospective studies demonstrating a cardioprotective effect of hydroxychloroquine in patients with SLE are needed. HCQ has proved to be effective in a number of autoimmune diseases including systemic lupus erythematosus SLE. Areas covered In this review the mechanisms of action, the efficacy, and the safety of HCQ in the management of patients with SLE have been reviewed. HCQ may reduce the risk of flares, allow the reduction of the dosage of steroids.

    Hydroxychloroquine is considered safer than chloroquine during pregnancy and lactation. If there is a of hydroxychloroquine, although studies have not usually confirmed this clinical impression.

    Hydroxychloroquine mechanism of action sle

    Plaquenil Hydroxychloroquine for Lupus - LupusCorner, Hydroxychloroquine - an overview ScienceDirect Topics

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  5. Hydroxychloroquine is also a disease-modifying anti-rheumatic drug DMARD that has immunomodulatory and anti-inflammatory effects. The exact hydroxychloroquine mechanism of action is unclear, although it does work to interrupt the communication of immune system cells to decrease swelling, pain, and joint damage. 1, 2, 3, 5

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    Lupus Systemic Lupus Erythematosus or SLE Systemic lupus erythematosus is a condition characterized by chronic inflammation of body tissues caused by autoimmune disease. Lupus can cause disease of the skin, heart, lungs, kidneys, joints, and nervous system. When only the skin is involved, the condition is called discoid lupus. The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis and systemic lupus erythematosus. These compounds lead to improvement of clinical and laboratory parameters, but their slow onset of action distinguishes them from glucocorticoids and nonsteroidal antiinflammatory agents. Hydroxychloroquine is an antimalarial agent that has been used in systemic lupus erythematosus and rheumatoid arthritis treatment for many years. Recently, novel mechanisms of action have been proposed, thereby broadening the therapeutic perspective of this medication.

     
  6. Sushkov Andrew New Member

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  7. PALITRA Guest

    Poisoning, deliberate or accidental, with drugs used to treat malaria, seems to be uncommon although data is not available from South Sudan. Chloroquine not cure for coronavirus –NMA – Punch Newspapers Chloroquine C18H26ClN3 - PubChem Fatal Chloroquine Poisoning A Rare Cause of Sudden Cardiac.
     
  8. Indian_Joe Moderator

    Chloroquine MedlinePlus Drug Information Chloroquine phosphate is used occasionally to decrease the symptoms of rheumatoid arthritis and to treat systemic and discoid lupus erythematosus, scleroderma, pemphigus, lichen planus, polymyositis, sarcoidosis, and porphyria cutanea tarda.

    Chloroquine Confirmed Effective as Coronavirus Cure.
     
  9. EugeneF New Member

    Methotrexate vs plaquenil side effects long term and short. Methotrexate vs plaquenil side effects long term and short term. I was recently diagnosed with an autoimmune disease that mainly fuses my joints together, but causes severe pain and fatigue. The only problem is the Plaquenil causes severe headaches that interfer with my daily activities also.

    What are the side effects of Plaquenil?