Tamoxifen versus femara

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    Tamoxifen versus femara


    The data show that letrozole, 2.5 mg once daily, is as effective in older, postmenopausal women as it is in younger postmenopausal women with advanced breast cancer. In addition, letrozole was more effective than tamoxifen in both younger and older patients. Presently, 48% of breast cancer cases occur in elderly women (aged 65 years and older) [1], and it is the most common cause of cancer death in women of that age group [2]. Demographic changes in the growing age segment of our population are dramatic: with the aging of the general population, the association between cancer and aging has become more evident and paramount as a pandemic public health concern. As such, formidable increases in the incidence and prevalence of breast cancer can be expected in the coming decades if the older population continues to expand at the present rate [1]. Eighty percent of breast tumors occurring in women aged 70 and older are rich in hormone receptors, while the remaining 20% of women have aggressive tumors that have few hormone receptors [3, 4]. Knowledge of the steroid receptor content of human breast cancer is important for deciding the proper treatment for advanced breast cancer. Endocrine therapy is the established treatment in women with hormone-sensitive tumors, as manifested by positive receptor status, a long disease-free interval, and primarily soft tissue disease. Many postmenopausal women take hormonal therapy medicine – either an aromatase inhibitor or tamoxifen – after breast cancer surgery and other treatments for hormone-receptor-positive, early-stage breast cancer. Hormonal therapy medicine can reduce the risk of the cancer coming back (recurrence). A new analysis of results from the BIG 1-98 trial found that the aromatase inhibitor Femara (chemical name: letrozole) improved both disease-free survival (living without the cancer growing) and overall survival (living whether or not the cancer grew) compared to tamoxifen in postmenopausal women diagnosed with estrogen-receptor-positive, HER2-negative breast cancer. The benefits of Femara over tamoxifen were most notable in treating lobular breast cancer compared to ductal breast cancer. Femara was also better at treating luminal B breast cancers with a high level of the protein Ki-67, which helps breast cancer cells grow. The study, "Relative effectiveness of letrozole compared with tamoxifen for patients with lobular carcinoma in the BIG 1-98 trial," was presented at the 2012 San Antonio Breast Cancer Symposium. Lobular breast cancer is breast cancer that begins in the milk-producing lobules, which empty out into the milk ducts that carry milk to the nipple.

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    J Steroid Biochem Mol Biol. 2003 Sep;863-5289-93. Letrozole versus tamoxifen in the treatment of advanced breast cancer and as neoadjuvant therapy. Women who received letrozole alone also had better overall survival at 8 years than women receiving tamoxifen alone 83.4 versus 81.2 percent. The differences between the groups were slightly greater in the analysis accounting for the crossover. By the way, i am not aware there are several brands of temoxifen. i have my chemo treatment in Bristish Columbia, tamoxifen is.

    Das Antiöstrogen Tamoxifen (NOLVADEX u.a.) senkt bei Frauen vor und nach den Wechseljahren Rückfallrate und Sterblichkeit bei lokalisiertem Brustkrebs mit positivem oder unbekanntem Hormonrezeptorstatus.1 Die Rezidivrate nach Abschluss der adjuvanten Therapie ist mit jährlich 2% bis 3%2 dennoch beträchtlich. Die durch fünfjährige Tamoxifeneinnahme erzielte Wirksamkeit lässt sich aber offensichtlich nicht weiter steigern. Nach derzeitigem Kenntnisstand bringt eine Verlängerung keinen zusätzlichen Nutzen, sondern scheint sogar zu schaden, möglicherweise wegen Entwicklung einer Abhängigkeit des Tumors von den partiellen östrogen-agonistischen Effekten des Mittels (a-t 1996; Nr. In mehreren randomisierten kontrollierten Studien wird inzwischen geprüft, ob eine Anschlusstherapie mit Aromatasehemmern wie Anastrozol (ARIMIDEX) oder Letrozol (FEMARA) die Rezidivrate und Sterblichkeit weiter senken kann.3 Aromatasehemmer blockieren in peripheren Geweben die Umwandlung von Androgenen in Östrogene und damit den Hauptweg der Östrogensynthese nach den Wechseljahren. Vor der Menopause sind Aromatasehemmer allein unwirksam. Sie sind bisher nur bei fortgeschrittenem Brustkrebs zugelassen, Anastrozol auch zur adjuvanten Behandlung, wenn Tamoxifen kontraindiziert ist. In einem noch nicht abgeschlossenen direkten Vergleich von Anastrozol mit Tamoxifen als primäre adjuvante Therapie nimmt nach einer Zwischenauswertung die krankheitsfreie Überlebenszeit unter Anastrozol zu, ein Vorteil im Hinblick auf die Gesamtsterblichkeit ist aber nicht belegt (a-t 2002; 33: 93-4). Eine Studie zur adjuvanten Anschlusstherapie mit Letrozol wird jetzt aufgrund der ersten Zwischenanalyse nach im Median 2,4 Jahren vorzeitig abgebrochen. uses cookies to improve performance by remembering your session ID when you navigate from page to page. Please set your browser to accept cookies to continue. This cookie stores just a session ID; no other information is captured. Accepting the NEJM cookie is necessary to use the website.

    Tamoxifen versus femara

    Letrozole or Tamoxifen in Treating Postmenopausal Women With., Study Confirms Letrozole Prevents More Breast Cancer.

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  7. The aromatase inhibitor Femara may equal the drug tamoxifen for women with estrogen-sensitive breast cancer, a new study shows.

    • Femara vs. Tamoxifen for Breast Cancer - WebMD.
    • Side effects of Tamoxifen compared to Letrozole - Breast Cancer..
    • Breast Cancer Survival Femara Better Than Tamoxifen.

    Das Antiöstrogen Tamoxifen NOLVADEX u.a. senkt bei Frauen vor und nach. mit Aromatasehemmern wie Anastrozol ARIMIDEX oder Letrozol FEMARA die. versus 1,6% nach 2,4 Jahren, der Unterschied ist jedoch nicht signifikant.4 One group of patients took either tamoxifen or Femara for five years. Another took tamoxifen for two years followed by three years of Femara or. Dec 2, 2011. In addition, 5 years of sequential treatment—either 2 years of letrozole followed by 3 years of tamoxifen or 2 years of tamoxifen followed by 3.

     
  8. qooler Guest

    This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information. To find the most current information, please enter your topic of interest into our search box. 21, 2011 -- Older women with early breast cancers are more likely to live longer and less likely to have the cancer come back when they take the drug Femara (letrozole) instead of tamoxifen, a long-term follow-up study shows. At an average follow-up of more than eight years, postmenopausal women who took Femara for five years after surgery were 20% less likely to have their breast cancer return and 21% less likely to die from their breast cancer compared to postmenopausal women who took tamoxifen. Aromatase inhibitors are now generally considered the hormonal treatment first used by most postmenopausal early breast cancer patients whose tumors are fueled by estrogen, but not all women can take the drugs. The drugs work by blocking the production of aromatase, which turns the hormone androgen into estrogen in the body. But because they don't stop the ovaries from making estrogen, they are not used to treat breast cancer patients who are still ovulating. There are more than 2.6 million breast cancer survivors living in the U. About 230,000 new breast cancers are expected to be diagnosed in the U. this year and about 40,000 women will die of the disease. The new updated analysis from the previously published Breast International Group (BIG) study adds to the evidence showing that aromatase inhibitors may be a more effective treatment than tamoxifen for postmenopausal women with estrogen-dependent tumors. Anastrozol Arimidex®, Exemestan Aromasin®, Letrozol Aromatasehemmer Eine kritische Bestandsaufnahme Compare Letrozole vs Tamoxifen - Treato
     
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