Metoprolol meds

Discussion in 'Pharmacy Canada' started by Legolas, 02-Sep-2019.

  1. dimaLi User

    Metoprolol meds


    Metoprolol is used for a number of conditions, including hypertension, angina, acute myocardial infarction, supraventricular tachycardia, ventricular tachycardia, congestive heart failure, and prevention of migraine headaches. receptors in the heart, metoprolol is also prescribed for off-label use in performance anxiety, social anxiety disorder, and other anxiety disorders. Metoprolol is sold in formulations that can be taken by mouth or given intravenously. Side effects, especially with higher doses, include dizziness, drowsiness, fatigue, diarrhea, unusual dreams, trouble sleeping, depression, and vision problems. Metoprolol may also reduce blood flow to the hands or feet, causing them to feel numb and cold; smoking may worsen this effect. Due to the high penetration across the blood-brain barrier, lipophilic beta blockers such as propranolol and metoprolol are more likely than other less lipophilic beta blockers to cause sleep disturbances such as insomnia and vivid dreams and nightmares. Serious side effects that are advised to be reported immediately include symptoms of bradycardia (resting heart rate slower than 60 beats per minute), persistent symptoms of dizziness, fainting and unusual fatigue, bluish discoloration of the fingers and toes, numbness/tingling/swelling of the hands or feet, sexual dysfunction, erectile dysfunction, hair loss, mental/mood changes, depression, breathing difficulty, cough, dyslipidemia and increased thirst. By Mike Mc Evoy Generic Name: Metoprolol (multiple manufacturers) Common Brand Name: Lopressor (Novartis Pharmaceuticals – U. S.) Popularity: 16th most commonly prescribed drug between 2002 – 2008 (U. S.) Classes: Beta-adrenergic blocker, antianginal, antiarrhythmic, antihypertensive, antimigraine. Treatment Uses — Angina pectoris, heart failure, mild to moderate high blood pressure, and to improve survival after heart attacks. Also effective in treating arrhythmias, pheochrocytoma, essential tremor and neuroleptic drug induced movement disorders, preventing migraine headaches, reducing eye pressures in glaucoma, and reducing the frequency of vasovagal syncopal episodes. May have a role in treatment of aggressive behavior, panic attacks, and reducing atherosclerosis. Widely used (off-label) by performers to reduce symptoms of stage fright.

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    Dispensing errors have occurred between topiramate Topamax and extended-release metoprolol Toprol-XL resulting from confused drug names. Additional. METOPROLOL me TOE proe lole is a beta-blocker. Beta-blockers reduce the workload on the heart and help it to beat more regularly. This medicine is used to treat high blood pressure and to prevent chest pain. Medicines that may cause interactions with metoprolol include atenolol, fluoxetine, and ibuprofen. This eMedTV resource offers a more complete list of drugs that may cause a negative interaction and discusses the possible complications involved.

    Metoprolol is a cardioselective β1-adrenergic blocking agent used for acute myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. It may also be used for supraventricular and tachyarrhythmias and prophylaxis for migraine headaches. Metoprolol is structurally similar to bisoprolol, acebutolol and atenolol in that it has two substituents in the para position of the benzene ring. The β1-selectivity of these agents is thought to be due in part to the large substituents in the para position. At low doses, metoprolol selectively blocks cardiac β1-adrenergic receptors with little activity against β2-adrenergic receptors of the lungs and vascular smooth muscle. Unlike propranolol and pindolol, metoprolol does not exhibit membrane-stabilizing or intrinsic sympathomimetic activity. Membrane-stabilizing effects are only observed at doses much higher than those needed for β-adrenergic blocking activity. Metoprolol possesses a single chiral centre and is administered as a racemic mixture. Absorption: Well absorbed after oral administration. Distribution: Crosses the blood-brain barrier, crosses the placenta; small amounts enter breast milk. Metabolism and Excretion: Mostly metabolized by the liver (primarily by CYP2D6; the CYP2D6 enzyme system exhibits genetic polymorphism); ~7% of population may be poor metabolizers and may have significantly ↑ metoprolol concentrations and an ↑ risk of adverse effects. TIME/ACTION PROFILE (cardiovascular effects)When switching from immediate-release to extended-release product, the same total daily dose can be used PO: (Adults) Antihypertensive/antianginal– 25–100 mg/day as a single dose initially or 2 divided doses; may be ↑ q 7 days as needed up to 450 mg/day (immediate-release) or 400 mg/day (extended-release) (for angina, give in divided doses). MI– 25–50 mg (starting 15 min after last IV dose) q 6 hr for 48 hr, then 100 mg twice daily. Heart failure– 12.5–25 mg once daily (of extended-release), can be doubled every 2 wk up to 200 mg/day. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Drug-Guide/51497/all/metoprolol. Migraine prevention– 50–100 mg 2–4 times daily (unlabeled). IV: (Adults) MI– 5 mg q 2 min for 3 doses, followed by oral dosing. Tablets (tartrate): 25 mg, 50 mg, 100 mg Cost: Generic: All strengths $7.18/100Extended-release tablets (succinate; Toprol XL): 25 mg, 50 mg, 100 mg, 200 mg Cost: Generic: 25 mg $35.68/100, 50 mg $41.93/100, 100 mg $53.95/100, 200 mg $84.54/100Solution for injection: 1 mg/m LIn Combination with:hydrochlorothiazide (Dutoprol, Lopressor HCT). See combination drugs.metoprolol is a sample topic from the Davis's Drug Guide.

    Metoprolol meds

    Metoprolol Lopressor Drug Whys -, Metoprolol Tartrate Oral Tablet 25Mg Drug Medication Dosage.

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  3. Metoprolol and metoprolol ER are both beta-blockers, and treat certain heart conditions by blocking the effects of the hormone, epinephrine, which causes the heart to beat slower. See More These 5 Types of Medications Can Cause Erectile Dysfunction

    • Metoprolol Prices, Coupons & Savings Tips - GoodRx.
    • Drug Interactions With Metoprolol - Heart Disease Home Page.
    • Alternative to Metoprolol Succinate.

    Introduction. Metoprolol is a cardioselective beta-blocker that is widely used in the treatment of hypertension and angina pectoris. Metoprolol has been linked to rare cases of drug induced liver injury. The tablets comprise a multiple unit system containing metoprolol succinate in a multitude of controlled release pellets. Each pellet acts as a separate drug. Drugs that are strong inhibitors of CYP2D6, such as quinidine, fluoxetine, paroxetine, and propafenone, were shown to double metoprolol concentrations; no information about moderate or weak inhibitors, but are likely to increase metoprolol concentration; closely monitor patients when the combination cannot be avoided

     
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