Description Metronidazole tablets are an antibiotic used to kill or prevent the growth of bacteria or other microorganisms and is approved for the treatment of inflammatory lesions and rosacea, vaginosis and vaginitis. It is used off-label to treat hepatic encephalopathy by reducing the excessive amount of ammonia-producing bacteria in the body. Original uses (on-label) Treatment of susceptible anaerobic bacterial and protozoal infections, topical treatment of inflammatory lesions and rosacea, bacterial vaginosis and vaginitis due to susceptible organisms (vaginal preparations). Potential side effects Uncoordinated gait, confusion, dizziness, hives, disulfiram-like reaction (flushing, nausea, vomiting), nausea, vomiting, constipation, diarrhea, metallic taste, darkened urine, blood disorders (low white blood cell count), weakness, flu-like syndrome. Vaginal preparation: stomach cramps, abdominal cramps, vaginitis, vaginal itching or swelling. Topical preparation: skin redness, itching, rash, dryness, worsening of rosacea. Drug interactions Cimetidine, benzodiazepines, calcium channel blockers, cyclosporine, remeron, nateglinide, nefazodone, sildenafil, tacrolimus, venlafaxine, lithium, phenytoin, phenobarbital, warfarin. Unnecessary exposure to metronidazole in breast-feeding infants should be avoided. Special information This drug has a black box warning regarding a carcinogenic effect noted in animals. Vaginal formulation: Do not engage in sexual intercourse during therapy. Flagyl is a medical product which has an antibacterial effect and is used for the treatment of protozoa infections. Due to its strong anti-protozoa effect the main active component of Flagyl – Metronidazole – is often used in gynecologic and urologic practice to treat the infectious diseases of genitals and urinary organs. The pharmacological action of Flagyl occurs because Metronidazole inhibits the synthesis of aminoacids in the cells of protozoan microorganisms as a result of which they die. Flagyl has a broad spectrum anti-protozoa and antibacterial action but it is not usually used for the treatment of the common aerobic and anaerobic infections. Often, Flagyl is used in combination with strong antibiotics to remove protozoa microorganisms such as Trichomonas vaginalis, Entamoeba histolytica, Lamblia intestinalis, Giardia intestinalis. According to the instruction for the use Flagyl is recommended in the treatment of protozoan infections: intestinal amebiasis, liver abscess, trichomoniasis, lambliasis, and trichomonas vaginitis/urethritis. Also, Flagyl is used for the treatment of the infections of bones and vessels, and also infections of the respiratory tracts which are caused by protozoa causative agents. 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Symptoms of a Flagyl overdose may include nausea, vomiting, dizziness, loss of balance or coordination, numbness and tingling, or seizures (convulsions). Seek emergency medical attention if you think you have overdosed on Flagyl. Take Flagyl precisely as it was recommenede to you by your doctor. Metronidazole is one of few antibacterial drugs which effectively destroys protozoa agents of the infections. It is not typical antibacterial product, therefore its pharmacological action has broader spectrum. Metronidazole provides antimicrobial, antibacterial, antiprotozoal, trichomonicidal, and antiulcer action. The drug is released in different medical forms and may be used for the treatment of the infections of the various sites. Due to this, Metronidazole has become a leading medicine for the treatment of the infections caused by protozoa organisms. These are infections which are not treatable by the usual antibiotics. 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