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    Isotretinoin is recommended for patients with moderate acne that produces scarring or distress, or for acne that persists following other treatments. A PHARMAC funded electronic decision support tool for isotretinoin prescribing is available from: Funded.php#isotretinoin Isotretinoin is highly teratogenic and is contraindicated in women if pregnancy is possible unless effective contraception is used (Table 1). Isotretinoin is subsidised subject to Special Authority approval; vocationally registered general practitioners or nurse practitioners working in a relevant scope of practice are able to prescribe provided they have up-to-date knowledge of the safety issues. Hyperlipidaemia is considered a relative contraindication. Patients with elevated lipids can usually be managed with close monitoring. Advise patients to avoid donating blood during treatment and for at least one month after treatment has finished. The approved dose of isotretinoin is calculated according to the patient’s weight, i.e. 500 micrograms per kg, daily (in one to two divided doses) for two to four weeks, increased if necessary to 1 mg per kg, daily, for 16 – 24 weeks; maximum cumulative dose 150 mg per kg, per course. Low-dose regimens of isotretinoin are generally considered to be as effective as weight-based dosing regimens. Prvé 3 vyššie uvedené účinné zložky sú uzatvorené do lipozómov. Účinky piatich hlavných aktívnych látok sa vzájomne dopĺňajú pri plnení ich rozhodujúcej funkcie, ktorou je ochrana medzibunkovej hmoty, dodávajúcej koži jej hlavné mechanické vlastnosti, a to pevnosť a pružnosť. Významné sú aj antienzymatické, antioxidačné a ochranné vlastnosti, výsledkom ktorých je výrazná ochrana kyseliny hyalurónovej a iných esenciálnych zložiek mimobunkovej hmoty kože, ochrana stien kapilár (čím sa predchádza tvorbe vyšších štádií rozacei) a hydratácia. Lipozómy predstavujú významný transportný systém, ktorý podstatne zvyšuje rýchlosť prenikania účinných látok cez kožnú bariéru a významne zvyšuje hĺbku ich prieniku, čím sa výrazne zvyšuje účinnosť ošetrovacích prípravkov, aplikovaných na povrch kože. HLAVNÉ PREDNOSTI PROTECTODERM LIPOSOME SÉRA Účinky prípravku PROTECTODERM LIPOSOME SÉRUM možno charakterizovať ako ochranu všetkých dôležitých zložiek medzibunkovej hmoty kože, stien kapilár a hydratáciu. Účinné látky z prípravku PROTECTODERM LIPOSOME SÉRUM na jednej strane chránia uvedené bielkoviny pred účinkami agresívnych enzýmov, ktoré štiepia ich molekuly, na druhej strane stimulujú novotvorbu kolagénu a elastínu, a tak prispievajú k ich obnove, a tým k spevneniu kože a kapilár. Okrem týchto účinkov pôsobia lipozómy, kyselina hyalurónová a výťažok z uhorky na kožu aj zvlhčujúco.

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