With concentrated malaria eradication efforts currently underway, monitoring drug resistance in clinical settings complemented by in vitro drug susceptibility assays and analysis of resistance markers, becomes critical to the implementation of an effective antimalarial drug policy. Understanding of the factors, which lead to the development and spread of drug resistance, is necessary to design optimal prevention and treatment strategies. Hydroxychloroquine methemoglobinemia Hydroxychloroquine and famotidine G6pd plaquenil Plaquenil use and weight and maculopathy Chloroquine has been the standard of care for P. falciparum malaria for more than 40 years but the spread of resistant parasites in all malaria endemic regions has led to abandonment of the drug. Severe adverse effects are rare. Resistance The parasite develops a membrane pump to flush out heme and transporter to flush out chloroquine. A mutation in the gene encoding for chloroquine resistance transporter protein PfCRT has a role in the development of resistance by Plasmodium. Chloroquine, or hydroxychloroquine, has been used to treat malaria since 1944. It can be given before exposure to malaria to prevent infection, and it can also be given as treatment afterward. Malaria is a disease that is caused by a parasite, unlike COVID-19. The development of resistance to drugs poses one of the greatest threats to malaria control and results in increased malaria morbidity and mortality. This review attempts to summarize the unique factors presented by malarial parasites that lead to the emergence and spread of drug resistance, and gives an overview of known resistance mechanisms to currently used antimalarial drugs. Chloroquine resistant malaria mechanism Chloroquine - Wikipedia, Antimalarial Drugs – Quinine, Quinidine, Sulfonamides & more Can plaquenil cause psoriatic arthritis Its mechanism of action is unknown; however, malarial parasites invade human red blood cells, and chloroquine may prevent malarial parasites from breaking down metabolizing hemoglobin in human red blood cells. Aralen chloroquine Malaria Drug Side Effects & Dosage. Chloroquine, an old malaria drug, may help treat novel.. Mechanisms of Resistance of Malaria Parasites to.. Learn about Chloroquine Mechanism of action and resistance in 2 minutes. Presenter Dr. Tanmay Mehta MD, DNB, PGDCTM Apr 24, 2018 Learn about Chloroquine Mechanism of action and resistance in 2 minutes. Presenter Dr. Tanmay Mehta MD, DNB, PGDCTM Chloroquine is used for the prophylaxis of malaria in areas of the world where the risk of chloroquine-resistant falciparum malaria is still low. It is also used with proguanil when chloroquine-resistant falciparum malaria is present.