This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information. To find the most current information, please enter your topic of interest into our search box. 14 (Health Day News) -- A drug used to treat enlarged prostate and male pattern baldness also reduces a man's risk of prostate cancer by nearly a third, according to a large new study. The findings on nearly 19,000 men also overturn earlier concerns that treatment with finasteride -- the agent in the prostate drug Proscar and the hair-loss drug Propecia -- might promote the development of more virulent prostate cancers in men who contract the disease, researchers said. Finasteride did not affect overall survival rates or survival rates after diagnosis with prostate cancer for men who did and did not receive the drug, said study lead author Dr. Ian Thompson, a urologist and professor at the University of Texas Health Science Center. "If indeed the more high-grade cancers in the men taking finasteride were real, we would expect to find a higher death rate," Thompson said. "The survival of these men was exactly the same." Published in the Aug. Twenty five years after it opened for enrollment, the landmark Prostate Cancer Prevention Trial has delivered a final verdict. Finasteride, a common hormone-blocking drug, reduces mens' risk of getting prostate cancer without increasing their risk of dying from the disease. Initial study findings suggested there may be a link between use of the drug and a more lethal form of prostate cancer, but long-term follow-up shows that is not true. Ian Thompson, Jr., principal investigator of SWOG's Prostate Cancer Prevention Trial, or PCPT, will deliver the findings May 19 at the Journal of Urology Lecture at the 2018 Annual American Urological Association Meeting in San Francisco. The meeting is the largest gathering of urologists in the world. "What we can now say is that finasteride not only significantly reduces a man's risk of prostate cancer, it is safe to use based on very long-term follow-up in our study," said Thompson. "In PCPT, we found no increased risk of prostate cancer death in men who took finasteride compared with men who did not. Prostate cancer is the most common cancer diagnosed in American men, and we have found an inexpensive, effective drug that can prevent it. I'm pleased to report that we've answered the questions and closed the book." Thompson is chair of SWOG's genitourinary cancer committee, overseeing development of all urologic cancer studies for the federally-funded cancer clinical trials group, and serves as president of CHRISTUS Santa Rosa Hospital—Medical Center in San Antonio, Texas and as emeritus professor at the University of Texas Health Science Center. He and his team set out to determine whether finasteride, a drug used to treat symptoms of prostate enlargement as well as male pattern baldness, would prevent prostate cancer in men over the age of 55. Motilium tablets to buy Is cialis generic Thompson 2003 The trial evaluated 18,000 men age 55 and older, lasted seven years, and evaluated finasteride for prostate cancer. Aug 28, 2013. A summary of results from a phase III trial that tested whether the drug finasteride could help prevent prostate cancer in men age 55 and older. In PCPT, we found no increased risk of prostate cancer death in men who took finasteride compared with men who did not. These results are. Long-term follow-up results from a phase III trial called the Prostate Cancer Prevention Trial (PCPT) continue to show that regular use of finasteride (Proscar®) for up to 7 years decreased the risk of low-grade prostate cancer in men age 55 and older compared with that in men who received a placebo. Although high-grade cancers were more common in the finasteride group, the finasteride and placebo groups had similar 15-year overall survival rates. New England Journal of Medicine (NEJM), August 14, 2013 (See the study abstract.)Launched in January 1994, the PCPT was a large randomized clinical trial designed to test whether the drug finasteride could help prevent prostate cancer in men age 55 and older. Finasteride blocks the activity of 5-alpha reductase, an enzyme that helps control the activity of the hormone testosterone. This hormone influences the size of the prostate and can fuel the growth of prostate tumors. Finasteride was approved by the Food and Drug Administration in 1992 for the treatment of benign prostatic hyperplasia and is also approved to treat male pattern baldness. It has not been approved for preventing prostate cancer. What do we know about Propecia and prostate cancer? Has research that seems to show a possible protective benefit for some men taking Propecia really changed what doctors recommend to men with a high risk of developing prostate cancer? Evidence has come forward that Propecia (finasteride) -- a drug used to treat male pattern baldness -- could possibly help in the prevention of prostate cancer in men with a high risk of developing the disease. Other studies have also shown that Propecia (or similar drugs) may delay the onset of prostate cancer in some men. It was long thought that Propecia or similar drugs might offer some protective benefits given how they work in the body. Propecia is one of a class of drugs that counteract the effects of testosterone in the body. Testosterone is known to be one of the major drivers of prostate cancer growth. Propecia causes prostate cancer Finasteride Are the Risks Worth it? - Johns Hopkins Hospital, Finasteride Reduces the Risk of Low-Grade Prostate Cancer in Men. Why does tadafil have to be taken under the tongue A drug used to treat enlarged prostate or hair loss in men has been shown to have a long-term protective effect against prostate cancer. Finasteride can reduce prostate cancer risk long term. Finasteride does not increase risk of prostate cancer death. Finasteride and Prostate Cancer A Commentary. Does finasteride prevent prostate cancer? No — it just prevents you from knowing that you have it, says Patrick C. Walsh, M. D. who worries that men taking this. Finasteride reduced risk for prostate cancer and did not increase the. Previously, the Prostate Cancer Prevention Trial showed finasteride. cancer death among men who took finasteride compared with men who did not. A summary of results from a phase III trial that tested whether the drug finasteride could help prevent prostate cancer in men age. Cancer Causes and Prevention.