In order to minimize the risks of infection and other potential complications with podiatric surgery in this patient population, this author reviews the literature and offers insights on whether medications for RA should be withdrawn, continued or modified during the perioperative period. Increasingly, the treatment of rheumatoid arthritis includes the utilization of immunosuppressive therapeutic agents. Hydroxychloroquine 200 Hydroxychloroquine tests Target of chloroquine Plaquenil bad dreams Commonly used DMARDs include Rheumatrex and Trexall methotrexate sodum, Plaquenil hydroxychloroquine sulfate, Arava leflunomide and Azulfidine sulfasalazine. Pros DMARDs not only help control symptoms, but they can also minimize joint damage and stave off future complications. Compare Methotrexate vs Sulfasalazine head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate rated 6.7/10 vs Sulfasalazine rated 5.7/10 in overall patient satisfaction. Leflunomide, sulfasalazine, and hydroxychloroquine are effective therapies in RA and are commonly employed in combination therapy. Although the precise mechanisms of action of the traditional DMARDs are incompletely understood, most have both anti-inflammatory and immunomodulatory actions. Louie and Ward demonstrated that in the state of California, rates of joint surgery for the treatment of RA declined in the 1990s and have continually diminished since that time.1 The authors concluded that the favorable long-term outcomes for the treatment of rheumatoid arthritis with newer agents have resulted in a decreased need for bone and joint surgery in patients afflicted with this disease. The effectiveness of disease modifying agents in reversing the progression of rheumatoid arthritis (RA) is illustrated by the reduced frequency with which patients with RA undergo surgery for bone and joint deformities. Methotrexate sulfasalazine hydroxychloroquine and leflunomide Leflunomide, Sulfasalazine and Hydroxychloroquine for., Methotrexate vs Sulfasalazine Comparison - Plaquenil tablet doses Ocular side effects of anti-rheumatic medications what a rheumatologist should know. Leflunomide is another systemic anti-metabolite used in the therapy of rheumatic diseases. can be used in low doses in lupus and rheumatoid arthritis patients as a steroid-sparing agent or synergistically with hydroxychloroquine. One of the major. Ocular side effects of anti-rheumatic medications what a.. Traditional DMARDs Methotrexate, Leflunomide.. What are the side effects of hydroxychloroquine and.. What are the side effects of using leflunomide Arava to treat rheumatoid arthritis RA? ANSWER Leflunomide Arava works about as well as methotrexate and can work even better in combination. Apr 13, 2005 The Combination of Leflunomide Arava and Methotrexate is Safe & Efficacious for the Treatment of Rheumatoid Arthritis April 13, 2005 By Arthritis Center Methotrexate MTX, an anti-metabolite that inhibits purine pathways, has been the hallmark of standard of care for many years in the treatment of rheumatoid arthritis RA. Disease-modifying antirheumatic drugs DMARDs may relieve more severe symptoms of psoriatic arthritis. Learn more about Methotrexate, Antimalarials, Corticosteroids, Acthar, Imuran, Leflunomide & Sulfasalazine.