Your doctor determines the cause by reviewing your medications, your signs and symptoms and, in some cases, other tests and procedures. High liver enzymes can be a result of lupus, and my rheumatologist said some of this is not uncommon in lupus patients. Does plaquenil weaken the immune system Hydroxychloroquine teratogenicity Dec 18, 2018 Liver Enzymes. The liver produces several enzymes involved in metabolism. Among them, the aminotransferases, also called the transaminases, ALT and AST, which function in protein metabolism, have particular diagnostic value, as they become elevated in several diseases, including those of the liver and gallbladder in addition to disorders of other tissues, including the heart and muscle. Aug 23, 2018 Heightened liver enzymes can often be an issue for monitoring with RA, particularly in relation to certain medications. Since your high tests came back before you started treatment, some other cause potentially separate from RA may be to blame. Herbal medicines and anti-tuberculosis medications, known to cause toxic hepatitis, can also induce increased liver enzyme levels in lupus patients. However, since most herbal medicines contain a mixture of various products, we could not ascertain what specific ingredient induced the increase in liver enzyme levels. PMID 19885660 When this happened to me, my symptoms included pervasive malaise, nausea, itching, and worsening of my overall health and lupus activity. Although it is uncommon, lupus can also attack a patient’s liver, causing a more pronounced elevation in liver enzymes, such as ASTs and ALTs. Plaquenil does increase liver enyzmes Elevated liver enzymes Causes - Mayo Clinic, Does anyone have RA with elevated liver enzymes. Moa of chloroquine in malariaHydroxychloroquine toxicity monitoringRetinal pigment epithelial mottling of macula plaquenilHydroxychloroquine sulfate pharmacological classAvn with hydroxychloroquine Elevated liver enzymes are usually a temporary sign. Liver enzyme levels may return to normal quickly if a person follows the doctor’s recommended treatment plan for the underlying condition. Elevated liver enzymes Causes, symptoms, tests, and treatment. Liver enzyme abnormalities in systemic lupus erythematosus a.. Plaquenil Uses, Dosage & Side Effects -. Cholesterol-reducing statins such as atorvastatin Lipitor – can cause certain liver enzyme levels to increase. While it is not unusual for patients taking statins to experience a mild spike in liver enzymes, the risk of liver failure from use is very low. In these patients, high doses of hydroxychloroquine may trigger liver damage. 9, 10, 17 From the community “I was on Plaquenil for 5 1/2 yrs with no liver problems but had to stop it because it had started to affect my retinas.” - Inspire member “I take 200 mg of Plaquenil a day. I was told it can take months to help and it did. My previous imaging tests and the liver biopsy showed healthy liver, no PBC, no autoimmune hepatitis. There doesn't seem to be a link between lupus activity and the enzymes. Have you experienced high liver enzymes due to lupus? My hepatologist and my rheumatologist can't agree whether mine are caused by lupus, they both seem to think that they.