Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Is chloroquine good to use to prevent malria How does hydroxychloroquine work in the body Aralen rheumatoid arthritis Focus on Eyes Long-term Plaquenil intake can affect your vision. Taking high doses or long-term treatment of Plaquenil, an anti-malaria drug used to treat lupus, can lead to vision problems. Feb 20, 2018 Focus on Eyes Long-term Plaquenil intake can affect your vision. Taking high doses or long-term treatment of Plaquenil, an anti-malaria drug used to treat lupus, can lead to vision problems. The main outcomes were toxicity as determined by characteristic visual field loss or retinal thinning and photoreceptor damage. They also examined risk factors and prevalence. The study findings revealed that when hydroxychloroquine was used at doses 5mg /kg, the risk of retinopathy was 1% in the first 5 yrs. 2% in 10 yrs. 20 % after 20 yrs. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Macular thinning and plaquenil Prescription Medications That Can Affect Age-Related Macular., Focus on Eyes Long-term Plaquenil intake can affect your vision Ophthalmologist for plaquenilAssay of chloroquine by non aqueous titrationChloroquine reviewNormal dosage daily for plaquenilFluoroquinolones and chloroquine Plaquenil is less toxic than chloroquine; however, long-term use of either drug can result in macular toxicity, leading to devastating irreversible vision loss. How to Succeed in Plaquenil Screenings. My Take on New Ocular Screening Guidelines for Plaquenil.. New Plaquenil Guidelines. Plaquenil induced retinal toxicity is reversible if detected early and plaquenil dosage altered or the medication discontinued. Even suspicious early plaquenil toxicity warrants communication with the patient’s treating physician, and meaningful coordination of care would include a report even if the findings are normal. Selective Thinning of the Perifoveal Inner Retina as an Early Sign of Hydroxychloroquine Retinal Toxicity Sirichai Pasadhika, 1 Gerald A Fishman, 1 Dongseok Choi, 2 and Mahnaz Shahidi 1 1 Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL Nov 01, 2015 H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity, which may be.