Chloroquine induced cardiomyopathy

Discussion in 'Hydroxychloroquine' started by Ufaweb, 05-Mar-2020.

  1. SMaria Moderator

    Chloroquine induced cardiomyopathy

    Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking chloroquine: Incidence not known Some side effects of chloroquine may occur that usually do not need medical attention.

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    Oct 15, 2012 CMR may serve as an increasingly important diagnostic modality in antimalarial cardiotoxicity for a number of reasons. Firstly, it is the reference standard for the assessment of LV and RV function and morphology, the latter also commonly abnormal in antimalarial cardiotoxicity. 7,11 –13,17,18 Secondly, CMR also plays a primary role in the exclusion of differential diagnoses. A 58 year old woman on long term treatment with chloroquine for systemic lupus erythematosus presented with cardiac conduction disorders and heart failure with hypertrophic cardiomyopathy, which was confirmed by histology to be related to chloroquine toxicity. The heart failure improved on stopping chloroquine treatment. McAllister HA Jr, Ferrans VJ, Hall RJ et al "Cholorquine-induced cardiomyopathy." Arch Pathol Lab Med 111 1987 953-6. 55. Baguet JP, Tremel F, Fabre M "Chloroquine cardiomyopathy with conduction disorders." Heart 81 1999 221-3. 56. Iglesias Cubero G, Rodriguez Reguero JJ, Rojo Ortega JM "Restrictive cardiomyopathy caused by chloroquine."

    Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine.

    Chloroquine induced cardiomyopathy

    Hydroxychloroquine-induced cardiomyopathy and heart., Chloroquine cardiomyopathy with conduction disorders Heart

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  6. Chloroquine-Induced Cardiomyopathy In this case, vacuolated cardiomyocytes and curvilinear body formation were observed on light and electron micros-copy, respectively, which are pathognomic findings of the intralysosomal accumulation of lipids. Cervera et al.1 recom-mended that a cardiac evaluation with an ECG and an oph-

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    In all, 22 cases of chloroquine-induced toxicity have been reported.1, 2, 3 Patients reported to have cardiotoxicity include 5 cases of cardiomyopathy with heart failure,4, 5 3 cases of hypertrophic cardiomyopathy,6, 7 one patient with restrictive heart disease, 8 one with restrictive heart disease and complete heart block with Doppler and. Chloroquine-induced itching is very common among black Africans 70%, but much less common in other races. It increases with age, and is so severe as to stop compliance with drug therapy. It is increased during malaria fever; its severity is correlated to the malaria parasite load in blood. Electron microscopy of the myocytes demonstrated dense, myeloid, and curvilinear bodies. The diagnosis of hydroxychloroquine-induced cardiomyopathy was made based on the clinical, hemodynamic, and pathologic findings. This is the first case report describing chloroquine-induced cardiomyopathy involving the heart conduction system.

  7. neox Well-Known Member

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  8. bumbaras Guest

    Hydroxychloroquine Dosage Guide with Precautions - Nov 25, 2019 Maintenance dose 200 to 400 mg 155 to 310 mg base orally daily Comments-Each dose should be taken with a meal or a glass of milk.-Retinopathy has been reported to be higher when the maintenance dose is exceeded.

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