Derm Net NZ Medical Editor: Dr Delwyn Dyall-Smith, Dermatologist, Wagga Wagga, NSW, Australia. However, following an identical dose of hydroxychloroquine and chloroquine, tissue levels of chloroquine are 2.5 times those of hydroxychloroquine. Derm Net NZ Editor in Chief: Adjunct Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand. Hydroxychloroquine is preferred due to its safer profile. Aps plaquenil Plaquenil used for hair loss Most of the patients described were African or of African descent with dark skin who had been exposed to the sun. One was a Hispanic patient who developed vitiligo-like skin depigmentation after 1 month of chloroquine therapy for cutaneous lupus erythematosus. The skin rapidly repigmented after discontinuation of chloroquine therapy. Chloroquine phosphate tablets, Chloroquine phosphate, USP, is a 4-aminoquinoline compound for oral administration. It is a white, odorless, bitter tasting, crystalline substance, freely soluble inwater. Chloroquine phosphate tablets are an antimalarial and amebicidal drug. Chlorpromazine is undoubtedly the drug most frequently implicated, causing violet or metallic gray purple pigmentation in areas exposed to the sun, mainly the face and limbs. 35 The mucous membranes are preserved, but the pigmentation may affect the nails and the exposed parts of the eye. 36 The other phenothiazines do not seem to show the same potential to produce hyperpigmentation, possibly due to structural differences that affect the melanin-binding sites. 4 Hydroxychloroquine is considered safer than chloroquine during pregnancy and lactation. If there is a of hydroxychloroquine, although studies have not usually confirmed this clinical impression. Chloroquine pigmentation Palate Hyperpigmentation Caused by Prolonged Use of the Anti., Chloroquine - FDA prescribing information, side effects. Sarafen and plaquenilPlaquenil 100mg tablets Mucocutaneous hyperpigmentation because of anti-malarial therapy has been reported since World War II 2; however, HCQ-associated hyperpigmentation seems to be less common than with other antimalarials such as chloroquine 3,4onset of HCQ-associated hyperpigmentation ranges from 3 months to 22 years following the initiation of therapy, with a median of 6.1 years 1. Hydroxychloroquine-induced Hyperpigmentation of the Skin.. Drug-Induced Hyperpigmentation Review and Case Series.. Hydroxychloroquine DermNet NZ. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Pigmentation varies, depending on the causative drug. It can involve accumulation of melanin, deposits of the drug or one of its metabolites, synthesis of pigments under the inﬂuence of the drug or deposition of iron after damage to the dermal vessels.11 Chloroquine and other quinine derivatives are used The anti-malarial agent chloroquine diphosphate, which is also used to treat immunological, dermatological, and rheumatological disorders, usually causes pigmentary changes in the oral mucosa. This report presents a case of palate pigmentation related to the prolonged use of chloroquine diphosphate caused by the deposition of drug metabolites in the mucosa.