Trametinib hydroxychloroquine pancreatic cancer

Discussion in 'Hydroxychloroquine Sulfate 200 Mg' started by Napochka, 20-Mar-2020.

  1. Guest

    Trametinib hydroxychloroquine pancreatic cancer

    Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties.

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    However, once the patient began receiving 2 mg of trametinib plus 1200 mg of hydroxychloroquine daily, his CA19-9 levels declined precipitously by ~ 95% over the ensuing 2 months indicative of response. There are also a number of clinical trials for pancreatic cancer, that may be worth considering. Good luck! BACKGROUND Trametinib, an oral mitogen/extracellular signal-related kinase MEK1/2 inhibitor, holds promise for malignancies with rat sarcoma RAS mutations, like pancreas cancer. This phase II study was designed to determine overall survival OS in patients with pancreas cancer treated with trametinib and gemcitabine. Researchers at the Huntsman Cancer Institute in Utah have identified a possible treatment for pancreatic cancer that could prolong life and provide a better quality of life in the end stages of.

    In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms).

    Trametinib hydroxychloroquine pancreatic cancer

    Taking a Different Approach to Pancreatic Cancer Treatment., A randomised, double-blind, placebo-controlled trial of.

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    FDA grants regular approval to dabrafenib and trametinib combination for metastatic NSCLC with BRAF V600E mutation. NGS test to detect multiple gene mutations for lung cancer in a single test. Summary The purpose of this phase I trial is to study the side effects and best dose of hydroxychloroquine when given together with trametinib in treating patients with pancreatic cancer that has spread to nearby tissue, lymph nodes or other places in the body and cannot be removed by surgery. So the researchers devised and tested a strategy where they blocked two energy sources using hydroxychloroquine and another common drug – trametinib. As expected, the researchers found that when they crippled the cancer cells two most significant pathways for energy the cancer cells began to suffer. Pancreatic Cancer and Energy Inhibition

  5. petr shmigol Well-Known Member

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