Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil and liver problems Hydroxychloroquine and sunshine Can you breastfeed while on plaquenil Annexin A5 AnxA5 is a potent anticoagulant protein that crystallizes over phospholipid bilayers PLBs, blocking their availability for coagulation reactions. Antiphospholipid antibodies disrupt AnxA5 binding, thereby accelerating coagulation reactions. Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. However, following an identical dose of hydroxychloroquine and chloroquine, tissue levels of chloroquine are 2.5 times those of hydroxychloroquine. Nicotine constricts the blood vessels in your brain and increases your blood pressure. Both make you more susceptible to stroke. With that many years in the medical field, you should have picked up. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil nicotine What is Plaquenil? - GoodRx, Hydroxychloroquine DermNet NZ Omphthamologists risks of hydroxychloroquine Plaquenil’s long half-life in the body can cause irreversible and progressive damage, Dr. Fung said. Similarly, one study reported that 16 women who’d taken hydroxychloroquine or chloroquine, or a combination of the agents, showed no improvement seven years after stopping drug therapy, and progression occurred in six of the cases. 2 Rx Side Effects New Plaquenil Guidelines and More.. Can nicotine have effects on plaquenil? Yahoo Answers. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Other oral medicines used in selected situations for this condition are the antimalarial hydroxychloroquine Plaquenil and the antibiotic metronidazole Flagyl, others. Immune response medicines Plaquenil is used in the treatment of sarcoidosis but its main use is in the treatment of malaria. One of the side effects of taking the drug is that it affects eye sight, and eye tests, especially field of vision tests need to be done every six months. Osteonecrosis, which is also called avascular necrosis AVN or aseptic necrosis, is the death of bone cells due to decreased blood flow. It can lead to pain and collapse of areas of bone. This collapse of bone, in turn, can lead to degenerative arthritis also called osteoarthritis of nearby joints.