You get more ACE2 receptors though if you smoke or have diabetes or if you lige a place with a lot of air pollution.https://gov/pmc/articles/PMC2911869/https://gov/pmc/articles/PMC1287568/I'm not a doctor so this is to be taken as medical advise or a reason to skip any precautions. I'm also certain the scientists will learn much more and perhaps change their views later. Hydroxychloroquine and white spots on skin Alternativesto taking plaquenil Ingredients in plaquenil She started me on medications and had me do even more bloodwork. This time one of them came back negative. On top of that the steroids she gave me did more damage than help. I went back to her office and she told me because the medication didn’t work I didn’t have it. Months later I find another rheumatologist who is willing to see me. Once I was off the plaquenil I had no further similar problems. So, didn't work for me but I have cardiac sarcoidosis as well as other organ involvement. My Johns Hopkins doctor has me on cellcept still on daily prednisone but hope to wean down after a while. I hope it works for you. Blessings, Becky Plaquenil didn't work for me. Methotrexate isn't so bad if you can deal with being stupidly tired and brain foggy one day a week, a day I dub "Methotrexate Hangover Day." Start with either, and keep in mind you may have to try a few different meds before you find one that works. I only write it, because reading this made me feel less nervous and it might help others too. You should also note that a slighter risk does not equate to immunity and that other health factors may make you more or less susceptible. Plaquenil did not work for me Plaquenil for RA?" Rheumatoid Arthritis Community - Support Group, Does Plaquenil work for anyone? - Sarcoidosis - Inspire Reviews on hydroxychloroquineYou use aralen for what Plaquenil for fatigue and pain. Sunvalleygal 04/12/2013. My rheumy stated the plaquenil wouldn't help me.though he didn't say why. I take MTX and I'm also on tramadol for pain. No NSAIDs for me. I take Nsaids for pain to get me through a work day when I am having a tough time. It seems to me you should be on a Dmard. Plaquenil for fatigue and pain DailyStrength. Plaquenil vs Methotrexate rheumatoid. Immune & Autoimmune - Lupus Plaquenil not working anymore. Plaquenil hydroxychloroquine is commonly used to help keep mild lupus-related problems, such as skin and joint disease, under control. this drug is also effective at preventing lupus flares. I started using plaquenil for the first few months after diagnosed with dermatomyositis. Then I went to John's Hopkins Myositis Center. They told me they do not usually start on plaquenil but skip straight to azathioprine. Did not see any improvement on plaquenil which is also their experience with most of their patients. My doctor has prescribed Plaquenil. He did not give me much of an explanation about the med's side effects --- other then the possible and rare eye issues. I will certainly see my eye doctor-- and will do what's necessary. However, I have read anecdotal 'stories' on various chat sites that suggest that Plaquenil can cause major hair loss. YIKES.