It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Plaquenil medication guide Plaquenil toxicity fundus autofluorescence Chloroquine resistant malaria may be treated with Furthermore, there was no evidence of teratogenic effects of hydroxychloroquine. Maternal Considerations. The available data suggest that hydroxychloroquine can be continued safely throughout pregnancy. 72, 74, 75 It seems that because of the risk of lupus flare, discontinuing therapy during pregnancy represents a greater danger to the fetus. Leukeran -- Teratogenic Agent There is evidence to indicate that exposure to Leukeran a chemotherapy drug during pregnancy may have a teratogenic effect on the fetus. A teratogen is a substance that can cause birth defects. Sep 13, 2019 Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. Hydroxychloroquine teratogenic effects Plaquenil Hydroxychloroquine - Side Effects, Dosage., Glossary for Hydroxychloroquine -- Teratogenic Agent. Hydroxychloroquine and ocular toxicity recommendations on screening 2009 Teratogenic Effects Human pregnancies resulting in live births have been reported in the literature and no increase in the rate of birth defects has been demonstrated. Embryonic deaths and malformations of anophthalmia and microphthalmia in the offspring have been reported when pregnant rats received large doses of chloroquine. DailyMed - HYDROXYCHLOROQUINE SULFATE tablet. Hydroxychloroquine Side Effects Common, Severe, Long Term.. Chloroquine Indications, Side Effects, Warnings -. Hydroxychloroquine can cross the placenta, but appears to have no effects on congenital defects, fetal death, or prematurity.7-9 Safety data on use of cyclosporine in pregnancy from transplant patients suggest a possible risk of preterm birth and low birth weight but no congenital defects. Thiopurines, azathioprine or mercaptopurine, are. Chloroquine appears to have a deleterious effect on sperm quality in vitro and in vivo in animal studies. Little data are available in males, unlike in pregnant women in which there is a large amount of reassuring data. The teratogenic risk related to the use of hydroxychloroquine is very low. The main serious effects that are associated with hydroxychloroquine exposure are very rare and involve cardiac and retinal toxicities. 31 Cardiac toxicity remains controversial; in the largest prospective study, the rate of heart conduction disorders during the 12-month follow-up period was similar to what is expected in the general population. 32 With regard to retinal toxicity, a follow-up study that included 2043 adult patients showed 0.1% of hydroxychloroquine-related retinopathy that.