Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Color vision changes associated with plaquenil toxicity Hydroxychloroquine side effects wikipedia Hydroxychloroquine retinopathy mechanism Plaquenil itching Binding of the drug to melanin in the RPE contributes to, or prolongs, its toxic effects. 2. Plaquenil toxicity is typically asymptomatic in early stages, but over time can lead to severe vision loss and retinal damage. Aug 16, 1999 The inhibitory effect of chloroquine on CYP2D6 activity in vivo has been difficult to demonstrate, and contradictory results on the inhibitory effect of chloroquine on debrisoquine hydroxylation have been published in humans 8, 9. Generally, all drugs metabolized by CYP2D6 may inhibit each other's metabolism. Patients use PLAQUENIL concomitantly with antidiabetic drugs, a decrease in doses of insulin or antidiabetic drugs may be required as PLAQUENIL may enhance the effects of hypoglycemic treatment see DRUG INTERACTIONS and ADVERSE REACTIONS. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Drug metabolism of plaquenil Review article prescribing medications in patients with., Influence of hydroxychloroquine on the bioavailability of. What are altered effects of hydroxychloroquineHydroxychloroquine induced cardiomyopathy and heart failure in twinsChloroquine effect on cell lysisHow does hydroxychloroquine work in the bodyDrugs that interact with plaquenil Following a single 200 mg oral dose of PLAQUENIL to healthy males, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 days. 50.3 ng/mL reached in 3.74 hours with a half-life of 2963 hours 123.5 days. PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION. Plaquenil Hydroxychloroquine Sulfate. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. An amount of 600 mg of hydroxychloroquine brand name Plaquenil was administered to these patients every day for 10 days. They reported "a significant decrease in viral load". The drug appeared to be responsible for a "rapid and effective speeding up of their healing process, and a sharp decrease in the amount of time they remained contagious". Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Drugs that prolong QT interval and other arrhythmogenic drugs PLAQUENIL prolongs the QT interval and should not be administered with other drugs that have the potential to induce cardiac arrhythmias. Also, there may be an increased risk of inducing ventricular arrhythmias if PLAQUENIL is used concomitantly with other arrhythmogenic drugs.