Quinolone and chloroquine resistance development

Discussion in 'Health Canada Drug Database' started by kassio, 22-Feb-2020.

  1. Solnce New Member

    Quinolone and chloroquine resistance development


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Thus, qnrB-mediated quinolone resistance and increased mutation ability are two events triggered by the same signal, namely, the SOS response. Quinolone resistance gene qnrB is upregulated by ciprofloxacin in a RecA/LexA-dependent manner, so that quinolone resistance development is an integral part of their mode of action in qnrB harboring. A quinolone antibiotic is a member of a large group of broad-spectrum bacteriocidals that share a bicyclic core structure related to the substance 4-quinolone. They are used in human and veterinary medicine to treat bacterial infections, as well as in animal husbandry. Our study of a number of halogenated alkyl and alkoxy 41H-quinolones highlights the potential for development of "endochin-like quinolones" ELQ, bearing an extended trifluoroalkyl moiety at the 3-position, that exhibit selective antiplasmodial effects in the low nanomolar range and inhibitory activity against chloroquine and atovaquone-resistant parasites.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Quinolone and chloroquine resistance development

    Drug Resistance in the Malaria-Endemic World - CDC, Quinolone antibiotic - Wikipedia

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  5. The first quinolone discovered was chloroquine, used primarily for the treatment and prevention of malaria. It was later followed by nalidixic acid, cinoxacin, rosoxacin, pipemidic acid, piromidic acid, and oxolinic acid. Quinolones that are in clinical development showing good activity against Gram-negative. Resistance to quinolone.

    • Quinolone - an overview ScienceDirect Topics.
    • Antimalarial quinolones Synthesis, potency, and..
    • Quinolones - SlideShare.

    Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best. Quinolone resistance associated with efflux pumps include modification of the major facilitator superfamily MFS of Gram-positive bacteria or the resistance–nodulation–division RND family, multiple antibiotic and toxin extrusion MATE, and ATP-binding cassette ABC of Gram-negative bacteria. 142 Mutations of efflux systems can alter their specificity for quinolones or cause upregulation. Chloroquine resistance is widespread in P. falciparum and is reported in P. vivax. Before using Chloroquine for prophylaxis, it should be ascertained whether Chloroquine is appropriate for use in the region to be visited by the traveler. Information regarding the geographic areas where resistance to Chloroquine occurs, is available at the.

     
  6. ALEKSss User

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Janumet Oral Uses, Side Effects, Interactions, Pictures. Hydroxychloroquine Indications, Side Effects, Warnings. Sjogren's Syndrome Center by
     
  7. hotbox User

    In people with SLE, lupus sore throat is a common experience. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus RA and Hydroxychloroquine How Effective is it for Rheumatoid. Plaquenil Hydroxychloroquine - Side Effects, Dosage, Interactions - Drugs
     
  8. svk-seo Moderator

    Hydroxychloroquine Uses, Dosage & Side Effects - Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria.

    Plaquenil and thrush - Doctor answers on HealthcareMagic
     
  9. job88 User

    Protecting your eyesight when taking Plaquenil Lupus. While side effects of corticosteroids are usually to blame, there is also the possibility of ocular damage associated with long-term use of the antimalarial drugs hydroxychloroquine brand name Plaquenil® and chloroquine. Improved vision screening tests and updated dosing guidelines are key to avoiding such complications.

    Hydroxychloroquine Reviews Everyday Health