Plaquenil radiation therapy

Discussion in 'Health Canada Drug Database' started by kinhon, 14-Mar-2020.

  1. Urvin New Member

    Plaquenil radiation therapy


    Listing a study does not mean it has been evaluated by the U. Giving hydroxychloroquine together with temozolomide and radiation therapy may kill more tumor cells. RATIONALE: Drugs used in chemotherapy, such as hydroxychloroquine and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.

    Hydroxychloroquine hypercalcemia Lariago chloroquine phosphate 250 mg

    Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Plaquenil Hydroxychloroquine belongs to a group of medications known as anti-inflammatories and antimalarials. It is used alone or in combination with other anti-arthritic medications to treat rheumatoid arthritis. It helps to reduce pain, stiffness, and swelling in joints. Commencement of protocol therapy began as soon as medically appropriate, but, no later than 3 mo after craniotomy. All subjects received conventional external beam RT as utilized by the Radiation Therapy Oncology Group. This consisted of 60 Gy in 30 fractions delivered with megavoltage machines.

    Cohorts of 3-6 patients receive escalating doses of hydroxychloroquine until the maximum tolerated dose (MTD) is determined. Complete 10 week cycle -Initiation Phase Maintenance cycles 1-6 HCQ daily TMZ D 1-5 150-200mg/m2 every 28 days. cohorts of three pts: dose levels: 200, 400, 800mg. Other: pharmacological study (PK) pts continue on treatment until tumor progression. PKs - correlatives will be collected in Phase 1 Radiation (RT)Phse 2: daily hydroxychloroquine (HCQ) (MTD 600mg) on 1st day of RT and concomitant temozolomide for 6wks during RT. Complete 10 week cycle -Initiation Phase Maintenance cycles 1-6 HCQ daily TMZ D 1-5 150-200mg/m2 every 28 days. Other: pharmacological study (PK) Pts will continue on treatment until tumor progression. PURPOSE: This phase I/II trial is studying the side effects and best dose of hydroxychloroquine when given together with radiation therapy and temozolomide and to see how well they work in treating patients with newly diagnosed glioblastoma multiforme. Complete 10 week cycle -Initiation Phase Maintenance cycles 1-6 HCQ daily TMZ D 1-5 150-200mg/m2 every 28 days. cohorts of three pts: dose levels: 200, 400, 800mg. Other: pharmacological study (PK) pts continue on treatment until tumor progression.

    Plaquenil radiation therapy

    Hydroxychloroquine, Radiation, and Temozolomide Treating., Plaquenil - Uses, Side Effects, Interactions -

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  5. Skin Reactions from Radiation Treatments Skin reactions are a common side effect of radiation treatments. They are caused when repeated doses of radiation pass through the skin. Skin reactions occur within “treatment fields.” Treatment fields are the parts of the body that are treated with radiation. Skin

    • Skin Reactions from Radiation Treatments.
    • A phase I/II trial of. - PubMed Central PMC.
    • Plaquenil Hydroxychloroquine - Side Effects, Dosage..

    Low-dose therapy is less likely to harm the retina, but if it does, early treatment may reverse the damage. Most adverse eye reactions occur in patients who take more than 400 mg of Plaquenil daily. The initial dosage range is 400 to 600 mg/day, but once the patient has a therapeutic response, the dose can be reduced. This phase I / II trial studies the side effects and best dose of hydroxychloroquine and how well CPI-613 and hydroxychloroquine work in treating patients with high risk myelodysplastic syndrome that has come back after hypomethylating therapy. CPI-613 is thought to kill cancer cells by turning off their mitochondria. Hydroxychloroquine in Treating Patients With Solid Tumors Undergoing Radiation Therapy for Bone Metastases. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government.

     
  6. Plasebo XenForo Moderator

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Medicines for the Prevention of Malaria While Traveling. Chloroquine, Potential Coronavirus Drug, Can Be Lethal to. Hydroxychloroquine - Wikipedia
     
  7. Flointer Guest

    In some cases, they may not be available in every strength or form as the brand-name drug. New Plaquenil Guidelines - Multimodal Imaging in Plaquenil Toxicity Hydroxychloroquine retinopathy A review of imaging
     
  8. Axion New Member

    How effective is Plaquenil for Fibromyalgia by duration. This is a reivew of how effective Plaquenil hydroxychloroquine sulfate is for Fibromyalgia and for what kind of people. The study is created by eHealthMe from 4 Plaquenil users and is updated continuously. On eHealthMe, you can evaluate side effects and drug interactions from 16 million FDA reports.

    Hydroxychloroquine User Reviews for Sjogren's. -