Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Side effects of chloroquine in pregnancy Hydroxychloroquine vision side effects Hydroxychloroquine Plaquenil; HCQ has been an important and effective drug for the treatment of lupus erythematosus and related autoimmune and inflammatory diseases for half a century, although its potential to cause retinal damage continues to raise concern among rheumatologists and ophthalmologists. Typical starting dose is 800 mg. This is followed by 400 mg three times 6 hours after the first dose, 24 hours after the first dose, and 48 hours after the first dose. Hydroxychloroquine is typically prescribed at 200mg/day to 400 mg/day. Dosage should be based on ideal body weight, not actual body weight because the medication is not retained in fatty tissues. 3,4,9 A 200mg tablet is safe for all but the smallest patients. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil dosage maculopathy Hydroxychloroquine Plaquenil Toxicity and Recommendations., Hydroxychloroquine Side Effects, Dosage, Uses, and More Color vision changes associated with plaquenil toxicityPlaquenil pmrChloroquine resistant malaria cdcDrug reactions in plaquenil Jan 03, 2020 Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. In a small percentage of patients, side effects may require temporary reduction of the initial dosage. Plaquenil Dosage Guide -. Does Patient with Lupus Have Plaquenil Retinopathy?. Plaquenil hydroxychloroquine sulfate dose, indications.. If a patient is on a dose that exceeds 5 mg/kg/day of real body weight, the prescribing physician should be contacted to ensure that the dose can be adjusted and medical risks are managed. Plaquenil is manufactured in only a 200 mg tablet The typical dosage is either 200 or 400 mg per day 200 mg daily puts anyone under 68 pounds at risk1 400 mg of Plaquenil daily puts anyone under 135 pounds at a higher risk for toxicity Therefore, 200mg of Plaquenil daily is going to be a safe dosage for virtually all adults13 The majority of cases of retinotoxicity have occurred in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine Plaquenil. This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day 200 bid.