Hydroxychloroquine retinopathy still alive and well

Discussion in 'Health Canada Drug Database' started by macsim, 27-Feb-2020.

  1. BlakW0lf Well-Known Member

    Hydroxychloroquine retinopathy still alive and well


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    This dose is extremely well-tolerated with minimal side-effects in most patients, and well below the threshold dose known to be associated with an increased risk of retinopathy. Given that the duration of pre-exposure prophylaxis could be on the order of months, the use of a dose well below the threshold associated with an increased risk of. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Hydroxychloroquine is a well-tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity1. Within the eye, hydroxychloroquine can adversely impact the cornea, ciliary body, and retina1

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Hydroxychloroquine retinopathy still alive and well

    Hydroxychloroquine retinopathy Eye, Hydroxychloroquine - Wikipedia

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  5. Hydroxychloroquine is classified as an anti-malarial drug. It is similar to chloroquine and is useful in treating several forms of malaria as well as lupus erythematosus and rheumatoid arthritis. Its mechanism of action is unknown. Malarial parasites invade human red blood cells.

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    Hydroxychloroquine, which overall is well tolerated by patients with SLE, has a protective effect on survival which is evident even after taking into consideration the factors associated with. Rates and Predictors of Hydroxychloroquine Retinal Toxicity in Patients With Rheumatoid Arthritis and Systemic Lupus Erythematosus FREDERICK WOLFE1 AND MICHAEL F. MARMOR2 Objective. Hydroxychloroquine HCQ retinopathy is of concern because of the potential seriousness of visual loss and the medicolegal consequences of failure to detect toxicity. Hydroxychloroquine Plaquenil; HCQ has been an important and effective drug for the treatment of lupus erythematosus and related autoimmune and inflammatory diseases for half a century, although its potential to cause retinal damage continues to raise concern among rheumatologists and ophthalmologists.

     
  6. reart User

    Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. Hydroxychloroquine Sulphate brands in Pakistan Karachi Pharmaceutical Laboratory - Pakistan Chloroquine Phosphate 250mg Uses Side Effects Price.
     
  7. Zizin XenForo Moderator

    The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. What are the side effects of hydroxychloroquine and. Hydroxychloroquine Side-effects, uses, time to work Hydroxychloroquine Plaquenil
     
  8. Dj Shilo XenForo Moderator

    A case of systemic lupus erythematosus presenting as. Aug 05, 2016 Background. Avascular necrosis AVN also known as osteonecrosis occur as a result of diverse etiology. Chronic inflammatory disorders, high-dose corticosteroids, excess alcohol intake, smoking, trauma, sickle cell disease, infections such as human immunodeficiency virus HIV, tuberculosis, meningococcal infections are some of the common causes AVN of bone 1, 2.

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