Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Increasing plaquenil dose Plaquenil and nephritis Drug interaction plaquenil and doxycycline Lupus traitement plaquenil Chloroquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis; it is active against the asexual erythrocytic forms of Plasmodium and Entamoeba species. Both adults and children should take one dose of chloroquine per week starting at least 1 week before. traveling to the area where malaria transmission occurs. They should take one dose per week while there, and for 4 consecutive weeks after leaving. The weekly dosage for adults is 300mg base 500mg salt. Chloroquine is a 9-aminoquinoline that has been known since 1934. Specifically synthesised to be used as an antimalarial agent, chloroquine was subsequently shown to have immunomodulatory properties that have encouraged its application in the treatment of autoimmune diseases such as rheumatoid arthritis. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine malaria dna binding theory Interaction of quinolines and artemisinin based antimalarials., Medicines for the Prevention of Malaria While Traveling. Malaria resistance to chloroquine The development and spread of highly drug-resistant parasites pose a central problem in the control of malaria. Understanding mechanisms that regulate genomic stability, such as DNA repair, in drug-resistant parasites and during drug treatment may help determine whether this rapid onset of resistance is due to an increase in the rate at which resistance-causing mutations are generated. This is. Defective DNA Repair as a Potential Mechanism for the Rapid.. Effects of chloroquine on viral infections an old drug.. Malaria, quinine and red cell lysis Parasitology.. The emergence of Plasmodium falciparum resistance to anti-malarial drugs has thwarted malaria control efforts and remains a major obstacle to malaria elimination throughout the world. Chloroquine was one of the first drugs to be used on a wide scale for the treatment of malaria. Ii Distortion of DNA caused by binding of ZEBRA, both a replication protein and a transactivator, may be detected as DNA “lesions” leading to ATM activation; loss of ATM activation following transfection of DNA binding domain mutants of ZEBRA supports options i and ii. DNA-BINDING THEORY This theory states that chloroquine binds to DNA, thereby inhibiting such essential cellular functions as DNA replication and RNA synthesis which in turn results in cell death.