They are most common among people with weak immune systems. People with certain health conditions may need to take medications with side effects that can weaken your immune system and put you at risk for fungal infections. Chloroquine phosphate amazon Chloroquine in hepatic amoebiasis Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. If you are on prednisone, methotrexate or another immunosuppressant you are immunocompromised. If your WBC count is low you would be considered immunocompromised. Being diagnosed with Sjogrens doesnt mean you are immunocompromised, but it can occur if antibodies attack your WBCs. Plaquenil is not considered an immunosuppressant according to my. Methotrexate is the cornerstone of treatment for RA and has demonstrated efficacy not only in treating the symptoms of RA but also to prevent the development of joint damage. Methotrexate does suppress the immune system, but serious infections with methotrexate are not common. Fungal infections can range from mild to life-threatening. Specifically, corticosteroids and TNF (tumor necrosis factor) inhibitors are two types of medications that can increase your chances of getting a fungal infection. Hydroxychloroquine immunocompromise DMARDs for Treating Rheumatoid Arthritis, Are people with Sjogren's considered "immunocompromised"? Chloroquine toxicity symptomsInjection dose of chloroquineChloroquine and anxiety Higher doses of medications that weaken your immune system are more likely to increase your risk of getting a fungal infection. 5,11,13,14. Click on the sections below to see lists of corticosteroids and TNF inhibitors that can increase the chances of getting a fungal infection. Medications that Weaken Your Immune System and Fungal.. Methotrexate Does it weaken my immune system?. Hydroxychloroquine Uses, Dosage & Side Effects -. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. Hydroxychloroquine received an overall rating of 7 out of 10 stars from 368 reviews. See what others have said about Hydroxychloroquine, including the effectiveness, ease of use and side effects. NOTE Plaquinil and hydroxychloroquine are essentially the same drug. The same effects should be expected from both drugs. 2. No, his immune system should not be forever compromised. I have an autoimmune disease and must take Plaquenil for the rest of my life in order to keep my immune system suppressed.