Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Does plaquenil have life long effects Hydroxychloroquine sulfatr interactions Hydroxychloroquine light sensitivity Hydroxychloroquine and cyclobenzaprine Find information about common, infrequent and rare side effects of Plaquenil Oral. PLAQUENIL hydroxychloroquine and the Eye. Download PDFVarious medications can affect the eyes and their drugs can be taken without damaging or changing the eyes in any way. However, a few systemic medications can cause damage to the eyes with subsequent vision changes. Damage to the retina, the light sensitive portion of the inner eye, can occur with long-term use of Plaquenil or chloroquine Aralen. With Plaquenil, however, the most commonly prescribed anti-malarial, this sort of damage occurs only in 1 out of 5,000 people who take the drug for five years or more. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. How can plaquenil affect your eyes Conditions Plaquenil-related Eye Problems Eugene Eye Care, PLAQUENIL hydroxychloroquine and the Eye Westford Hydroxychloroquine causing rash whereOct en face retina mesaurements plaquenilHydroxychloroquine label informationPlaquenil and humira I think you need to discuss this issue with your RD. Let him or her know you want some control, but not to make your immune system go permanently insane. I do think that Plaquenil is the mildest drug you can find. I think they all get stronger and more immune-suppressant from there, but I might be wrong! Plaquenil and its affect on the immune system DailyStrength. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. The Risk of Retinal Toxicity with Plaquenil. Plaquenil stays in your body for about 3 months. If you must stop it, it will take a while for the side effects to go away. You should have an eye examination every year to prevent a very rare but serious eye problem. Less than one person in 5,000 develops the problem. Only an eye doctor can see if you have a problem with your retina. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects.