"Look at everything—every time" is a mantra many of us have humming in the background as we go through our clinical day. Accordingly, providing screening examinations for high-risk medications, such as hydroxychloroquine, is a natural service for our profession. How does plaquenil affect the eyes What are plaquenil deposits However, it was written in a small window of time between publication of the articles that have amplified knowledge of this disease and adoption of this knowledge into a new set of American Academy of Ophthalmology screening recommendations, which have just been published. 3 This 2016 revision modifies key points from the previous 2011. This is a webpage on the US Preventive Services Task Force USPSTF site What are the current AAO guidelines for monitoring? The AAO revised its guidelines on screening for antimalarial toxicity in 2011 and again in March 2016 16, 21. Following a baseline examination, annual screening should begin after 5 years of use, when toxicity starts to become more common. The retinopathy is hallmarked by parafoveal changes within the retina. Hydroxychloroquine is an analogue to the much older drug chloroquine. Hydroxychloroquine is most frequently used for the management of lupus and rheumatoid arthritis; however, it is now being applied to treatments in adjunctive cancer therapy, diabetes, and heart disease. New plaquenil screening guidelines 2016 Recommendations on Screening for Chloroquine and., Published Recommendations - US Preventive Services Task Force How much is generic plaquenilWhat is chloroquine base Ahn SJ, Joung J, Lim HW, Lee BR. Optical Coherence Tomography Protocols for Screening of Hydroxychloroquine Retinopathy in Asian Patients. Am J Ophthalmol. 2017 Sep 27. Guideline AAO Quality of Care Secretariat, Hoskins Center for Quality Eye Care. Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy - 2016. Chloroquine and Hydroxychloroquine Toxicity Guidelines Guidelines Summary. New Perspectives in Rheumatology Avoiding Antimalarial Toxicity.. Hydroxychloroquine and Risk of Diabetes in Patients With Rheumatoid.. Based on this study the American Academy of Ophthalmology recommended new screening guidelines in 2011. The same study revealed that the most important predictor of toxicity was the duration of use cumulative dose and that age, the daily dose, and patient weight did not correlate significantly with HCQ toxicity. Thomas is enthusiastic about the updated guidelines, although he worries that the new dosing recommendations have not been widely disseminated to rheumatologists. “I think people with lupus can make a difference by pointing out the new guidelines to their rheumatologists,” he says. “Plaquenil is not deposited into fat,” he explains. Aug 30, 2011 Newer guidelines state that daily dose 5mg/kg of real weight/day can lead to toxicity. Retinal toxicity is irreversible and can progress after cessation of hydroxychloroquine, thus early screening is important to limit potential vision loss. Baseline screening and annual screening after five years is recommended.