Methotrexate is one of the most commonly used drugs to treat RA. However, it can decrease the levels of an important vitamin in your body called folate. Aralen dosis Chloroquine cathepsin Plaquenil eye exam form Hi. I take 20 mg of Methotrexate weekly, 3 mg of folic acid daily, & 400 mg of Plaquenil daily. The Methotrexate makes me extremely nauseous. I think it causes more hair loss although it hard to tell since Lupus & Hashimoto’s also cause hair loss. A weekly dose of methotrexate can cause unpleasant side effects, so Dooley recommends taking it when you have a couple of days off. For example, on Fridays, if you work during the week. “If you don’t feel 100 percent afterward, you have the weekend to get through it,” she says. It’s also important to avoid alcohol while taking methotrexate. Compare Methotrexate vs Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. Your doctor may suggest you take a folic acid supplement, which is a manufactured form of folate. This leads to a side effect of methotrexate called folate deficiency. Methotrexate and folic acid and plaquenil for lupus Immune & Autoimmune - Lupus methotrexate and leucovorin, Getting the most from your lupus medications Lupus. Plaquenil side effects vaginalPlaquenil liquid form Protocolled treatment of RA patients at both clinics consisted of MTX 25 mg/week reaching maximum dose within 4–8 weeks, preferably subcutaneously, and HCQ 400 mg/day as soon as feasible after diagnosis. Folic acid 10 mg/week is standard-prescribed to minimize MTX side effects. Effects of methotrexate and hydroxychloroquine combination therapy vs.. Methotrexate vs Plaquenil Comparison -. Methotrexate Managing Side Effects Arthritis Foundation. Hi JJinIN- I am recently diagnosed with lupus. My rheumatologist prescribed plaquenil, neurontin, prednisone, methotrexate, folic acid, and reglan. I take 7.5mg of the methotrexate weekly and I started three weeks ago. I have had no problems at all with nausea, diarrhea, or any other symptoms. Methotrexate is a potent folic acid antagonist and so many doctors prescribe folic acid to help with the side effects of methotrexate, such as nausea. But she has MTHFR and folic acid is toxic for her, hence he switched her to the methylated version, L-5-Methylfolate. Side effects can develop if the methylfolate dose is too high. Has anyone experienced any hair loss while on Methotrexate? I'm currently on 10mg once a week and have noticed an increase in hair loss. My doctor has also increased my folic acid dosage in hopes with helping it. I'm getting married in the fall and don't want to be bald by that day.