Treatment of porphyria cutanea tarda with chloroquine

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  1. karabasа User

    Treatment of porphyria cutanea tarda with chloroquine


    Porphyria Cutanea Tarda (PCT) is a rare disorder characterized by painful, blistering skin lesions that develop on sun-exposed skin (photosensitivity). Affected skin is fragile and may peel or blister after minor trauma. PCT is essentially an acquired disease, but some individuals have a genetic (autosomal dominant) deficiency of UROD that contributes to development of PCT.

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    Wallace DJ. The use of chloroquine and hydroxychloroquine for non-infectious conditions other than rheumatoid arthritis or lupus a critical review. Lupus. 1996; 5Suppl 1S59-64. 117. Petersen CS, Thomsen K. High-dose hydroxychloroquine treatment of porphyria cutanea tarda. Porphyria cutanea tarda PCT is common in Ethiopia and invariably affects the liver. Treatment by abstension from alcohol and avoidance of direct sunlight often failed to achieve lasting improvement. Common treatment options include phlebotomy, which is the removal of blood to reduce iron. chloroquine Aralen. hydroxychloroquine Plaquenil. pain medications. iron chelators. treating the diseases that cause the porphyria cutanea tarda, such as HCV or HIV.

    Most individuals with the inherited enzyme deficiency remain latent and never have symptoms. These individuals are referred to as having "familial PCT".

    Treatment of porphyria cutanea tarda with chloroquine

    Hydroxychloroquine DermNet NZ, Chloroquine in the treatment of porphyria cutanea tarda.

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  7. Two cases of infantile porphyria cutanea tarda successful treatment with oral S-adenosyl-L-methionine and low-dose oral chloroquine. Br J Dermatol. 1987 Mar. 1163407-15. Bruce AJ, Ahmed I. Childhood-onset porphyria cutanea tarda successful therapy with low-dose hydroxychloroquine Plaquenil.

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    Feb 27, 2019 Please use one of the following formats to cite this article in your essay, paper or report APA. Khetrapal, Afsaneh. 2019, February 27. Treatment of Porphyria cutanea tarda. Chloroquine treatment can induce porphyria attacks within the first couple of months of treatment due to the mass mobilization of porphyrins from the liver into the blood stream. Complete remission can be seen within 6–12 months as each dose of antimalarial can only remove a finite amount of porphyrins and there are generally decades of accumulation to be cleared. The skin lesions of pseudoporphyria closely resemble those seen in cutaneous forms of porphyria including porphyria cutanea tarda. Pseudoporphyria can occur at any age. Women are affected more often than men.

     
  8. GTM Guest

    Pain patients who do not respond to the analgesic properties of the most commonly used opioids have a significant chance of being genetically incapable of generating the clinically-active metabolite of these medications. Interactions between Plaquenil Oral and selected-cyp2d6. IN VITRO METABOLISM OF CHLOROQUINE IDENTIFICATION OF CYP2C8. Association of Polymorphisms of Cytochrome P450 2D6 With.
     
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  10. Potap User

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