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  8. no4ka Moderator

    EBM Focus - Volume 9, Issue 1 Read the Complete EBM Focus and Earn CME Cases of mild-to-moderate croup are often treated with corticosteroids, mostly based on results from randomized trials in emergency department settings. A recent Cochrane review demonstrated that corticosteroid treatment (dexamethasone in most trials) improves croup symptoms and reduces return visits or readmissions (Cochrane Database Syst Rev. 2011 Jan 19;(1): CD001955), and a high-quality randomized trial has shown that a single course of dexamethasone reduces symptom severity in children with mild croup (N Engl J Med. However, surveys have shown that the type of steroid used can vary across practices. A 3-day course of prednisolone is commonly prescribed by primary care pediatricians, but the clinical evidence supporting its use is limited, especially in settings outside the emergency department. Now, a community-based randomized trial has compared a 3-day course of prednisolone to a single course of dexamethasone in children with mild-to-moderate croup. A total of 87 children aged 1-8 years were randomized to prednisolone 2 mg/kg/day orally for 3 days vs. a single dose of dexamethasone 0.6 mg/kg orally plus 2 doses of placebo on successive days. Selecting an Oral Prednisolone Liquid for Children - US Pharmacist Welcome to Prednisolone hoalkybb Prednisolone for 3 Days May Be an Alternative to Dexamethasone.
     
  9. mexxa Moderator

    At any given time, more than 10 million women in the United States are pregnant or lactating, and exposing a fetus or newborn to antibiotics can pose a unique threat. Changes during pregnancy and lactation also can trigger pharmacokinetic and pharmacodynamic modifications that alter the effectiveness of antibiotics. Nahum and colleagues reviewed the literature on antibiotic use to provide updated, evidence-based information on antibiotic use in women who are pregnant or lactating. The researchers examined published medical literature, sources on teratogenicity and prescribing for women who are lactating or pregnant, and they abstracted data from product labels for drugs approved by the U. Food and Drug Administration (FDA) for use during pregnancy. The authors identified 124 references that covered 11 commonly prescribed antibiotics, all of which cross the placenta and are excreted in human breast milk. There was no teratogenic potential for penicillins G and V potassium (V-Cillink); unlikely potential for amoxicillin, chloramphenicol (Chloromycetin), ciprofloxacin (Cipro), doxycycline (Vibramycin), levofloxacin (Levaquin), and rifampin (Rifadin); and undetermined potential for clindamycin (Cleocin), vancomycin, and gentamicin. All agents were FDA Pregnancy Category B (amoxicillin, clindamycin, penicillin G, penicillin V potassium, and vancomycin) or C (chloramphenicol, ciprofloxacin, gentamicin, levofloxacin, and rifampin), except for doxycycline, which was category D. Einsatz von Antibiotika in der zahnärztlichen Praxis - dgzmk Amoxicillin Commonly Prescribed Medications in Pediatric. Antibiotic Use During Pregnancy and Lactation - Tips From Other.
     
  10. Beskoff Guest

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