It is also associated with the development of blood cancer (Burkitt's lymphoma) and is classified as Group 2A carcinogen. The species originated from the malarial parasite Laverania found in gorillas, around 10,000 years ago. Chloroquine action and target Plaquenil hypoglycemia Chloroquine in vivo Chloroquine is used extensively in malaria endemic areas in Africa to treat the uncomplicated form of Plasmodium falciparum malaria. However, the efficiency of chloroquine has been severely impacted by the recent development of chloroquine resistant plasmodium falciparum parasites. The development of chloroquine resistance by malaria parasites is increasing at an alarming rate especially in the tropical countries where it is used extensively as an antimalarial drug 2. However, a recent report from the Artibonite Valley north of Port-au-Prince documented that the P. falciparum chloroquine resistance transporter pfcrt haplotypes were detected in 5 6% of 79 blood samples from Haitians with blood smears positive for P. falciparum parasites. Although this report did not include clinical data, did not. Since the first documentation of P. falciparum chloroquine resistance in the 1950s, resistant strains have appeared throughout East and West Africa, Southeast Asia, and South America. The effectiveness of chloroquine against P. falciparum has declined as resistant strains of the parasite evolved. They effectively neutralize the drug via a mechanism that drains chloroquine away from the digestive vacuole. Ronald Ross discovered its transmission by mosquito in 1897. Alphonse Laveran was the first to identify the parasite in 1880, and named it Oscillaria malariae. Chloroquine p falciprum A Molecular Marker for Chloroquine-Resistant Falciparum., Lack of Evidence for Chloroquine-Resistant Plasmodium. Substitutes for plaquenilChloroquine metabolismSevere itching plaquenilChloroquine hydrochloride physicochemical properties Ferroquine 5 is ∼22 times more potent than chloroquine against resistant strain of P. falciparum in vitro. After a 4-day in vivo test in mice infected with P. berghei NS, only 20% showed recrudescence when observed for 60 days, whereas all mice treated with CQ showed recrudescence. 195,196 Chloroquine - an overview ScienceDirect Topics. Chloroquine - Wikipedia. Chloroquine - FDA prescribing information, side effects and uses. Chloroquine is an aminoquinoline that is quinoline which is substituted at position 4 by a 5-diethylaminopentan-2-ylamino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis. The locus containing the P. falciparum chloroquine resistance transporter gene pfcrt was initially mapped by classical genetic studies as being crucial to the development of CQ resistance, with. Oct 04, 2002 Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct proof of a causal relationship has remained elusive and most models have posited a multigenic basis of resistance.