Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Mylan hydroxychloroquine ingredients Chloroquine macrophages The mode of action of chloroquine is still controversial. Proposed mechanisms of action include 1 DNA intercalation, 2 lysosome accumulation and 3 binding to ferriprotoporphyrin IX. Recent data suggest that intercalation into parasite DNA can occur at physiological concentrations of the drug. Chloroquine inhibits glioma cell growth and viability in culture. A Assessment of cell growth rates in glioma cells with known functional status of p53. 31 Cells were treated with a range of chloroquine concentrations indicated in the legends. B Assessment of cell death rates in glioma cells lines with wtp53 left panel or deficient p53 function middle and right panels. J. Am. Chem. Soc. All Publications/Website. OR SEARCH CITATIONS The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine intercalating Chloroquine for Treatment of Glioblastoma Multiforme RxWiki, Chloroquine activates the p53 pathway and induces. Plaquenil toxicity in macular oct layer changes Uses Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live. Chloroquine Oral Uses, Side Effects, Interactions.. Synthetic models related to DNA intercalating molecules.. Chloroquine Aralen - Side Effects, Dosage, Interactions.. Chloroquine could also be acting directly on DNA, altering the expression of Plasmodium genes. Early work on this drug has shown that chloroquine can act as DNA-intercalating agent 19 and this mechanism was used to explain the antimalarial effect of the drug 20. Chloroquine is a well known anti-malarial agent, apart from which is a lysosomotropic agent, was used along with intercalating agent like methylene blue and anti-viral agents to treat clinically confirmed CHB patients. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme.