It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. How is drug chloroquine administered Difference between primaquine and chloroquine The investigators treated these APS mice with hydroxychloroquine, finding that the treatment improved endothelium-dependent dilation at three weeks. The research, published Nov. 6 in PloS One, also indicated that hydroxychloroquine can improve nitric oxide synthase coupling and reduce oxidative stress. Hydroxychloroquine HCQ was suggested to play a role in lowering antiphospholipid antibody titers and preventing thrombotic recurrences in patients with systemic lupus erythematosus, but few data are available in patients with primary antiphospholipid syndrome PAPS. Hydroxychloroquine is expected to work in APS by stopping platelets clumping together, reducing production of antiphospholipid antibodies and lowering cholesterol levels. Together, these effects are expected to reduce the risk of blood clots. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine aps Hydroxychloroquine Side-effects, uses, time to work, Long-term use of hydroxychloroquine reduces. Chloroquine phosphate mwChloroquine reduce cell viabilityHydroxychloroquine 부작용Hydroxychloroquine sulfate 200 mg priceHair loss caused by plaquenil Potential New Approaches in APS Prevention/Treatment B-cell Inhibition As discussed in the HSS article Antiphospholipid Syndrome. Hydroxychloroquine HCQ Hydroxychloroquine. Statins Statins are cholesterol-lowering agents that may be protective against blood clots by. Complement. Managing and Treating Lupus and Antiphospholipid Syndrome.. EU/3/16/1820 European Medicines Agency. Antiphospholipid Syndrome Medication Anticoagulants.. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Usual Adult Dose for Rheumatoid Arthritis. -Initial dose 400 to 600 mg 310 to 465 mg base orally once a day to optimum response usually 4 to 12 weeks -Maintenance dose 200 to 400 mg 155 to 310 mg base orally once a day Dose adjustment The dose may need to be reduced temporarily if adverse side effects occur; Hydroxychloroquine HCQ reduces the risk of thrombosis in APS animal models. In a CD1 mouse model, a significant increase in both the size of the thrombus and the duration of time that the clot persisted were observed in mice were injected with IgG and IgM-aCL antibodies obtained from patients with APS, when compared with control animals.