Alternatively, we suggest using this opportunity to take a little break from work and read some of the interesting articles below. Summary Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Hydroxychloroquine and yellow fever vaccine Plaquenil autoimmune hepatitis Plaquenil pregnancy category Lupus fog plaquenil Aug 11, 2014 The anti-cancer effect of the antimalarial agent chloroquine when combined with conventional chemotherapy has been well documented. To date, it was assumed that chloroquine increases the. The Autophagy Inhibitor Chloroquine Overcomes the Innate Resistance of Wild-Type EGFR Non-Small-Cell Lung Cancer Cells to Erlotinib. E Sunami, et al. Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer. T Kometani, et al. Sensitivity to gefitinib Iressa, ZD1839 in non-small cell lung cancer cell lines. Autophagy and cancer. A large body of evidence suggests that the relationship between autophagy and cancer is complex.42, 43 On the one hand, autophagy appears to inhibit malignant transformation, reflecting its capability to limit the accumulation of potentially oncogenic entities like depolarized mitochondria which overproduce potentially genotoxic reactive oxygen species, ROS. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties. Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. Chloroquine lung cancer Malaria drugs could help to combat cancer, The Autophagy Inhibitor Chloroquine Overcomes the Innate. Plaquenil et allergie soleilMechanism of action of chloroquine pdfChloroquine autophagy lc3bLichen planus hydroxychloroquine Strange as it may sound, but it is true. Yes, this is what a group of researchers from Harvard Medical School recently reported in a reputed journal. I believe most of us especially those living in India and Africa, are well aware of Chloroquine, which is known as one of the most widely and successfully used first generation anti-malarial drug. Chloroquine and Cancer Treatment - Biomedical Research, A.. Chloroquine and hydroxychloroquine for cancer therapy. Chloroquine as an Anti-Autophagy Drug in Stage IV Small Cell.. To investigate if the ability of pCQ to inhibit cancer cell migration and invasion in vitro translates into decreased metastasis in vivo, we used an experimental lung metastasis model of the 4T1 breast cancer. In this model, cancer cells are injected intravenously i.v. to colonize the lung and form lung metastasis. Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice. OncoImmunology Vol. 6, No. 11, e1356151. Chloroquines are expected to have diverse effects on cancer progression. Inhibition of late autophagy can affect cell survival, as well as antigen processing and presentation in the immune system. Co.