The doctor said that given where I am right now (constant low level pain and light swelling of my hands and wrists but no joint damage showing up on xrays or the ultrasound), she gave me a choice of starting on either Plaquenil or Methotrexate. She went over some info on each drug and then gave me some time to think about which would be better for me. My largest concerns center around the side effects of each... Cutaneous hyperpigmentation during therapy with hydroxychloroquine Can plaquenil make joint pain worse Hydroxychloroquine 400 mg side effects I am on both methotrexate and plaquenil. I have been on plaquenil for over a year and a half and methotrexate since September. I have had no side effects from either one. I get my eyes checked every six months and I am now at once a month on blood work for my liver enzymes used to be every 2 weeks. Methotrexate Moderate Hydroxychloroquine may reduce the renal clearance of methotrexate; the exact mechanism of this interaction is unknown. The mean AUC of methotrexate was increased 52% and the mean Cmax was reduced 17% when a single dose of methotrexate was given with a dose of hydroxychloroquine 200 mg oral. Hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. I also want to be sure that I'm taking a drug that will slow/stop the progression of the disease. With Plaquenil, the possibility of permanent vision damage scares me. Plaquenil or methotrexate Compare Plaquenil vs Methotrexate -, Plaquenil hydroxychloroquine sulfate dose, indications. Plaquenil retinal detachment Hydroxychloroquine is a less commonly utilized disease modifying anti-rheumatic medication. It is an anti-malarial medication. There is no indication that Plaquenil requires discontinuation in the perioperative period. In Conclusion. The effect of disease modifying agents on surgical outcome is difficult to assess. A Guide To Perioperative Management Of The Rheumatoid Patient.. Methotrexate and plaquenil -. Methotrexate vs Plaquenil? -. Hello thanks for your time. I started both of these ten weeks ago, I'm on 400mg hydroxy and 25mg of methotrexate. Last week I got in such a state about having to take them and it's got to a point where I constantly feel sick because I'm so anxious of having them, so I've been taken off hydroxychloroquine for two weeks so that now I only have medication on a Monday, I thought this would help. Plaquenil hydroxychloroquine and Rheumatrex and Trexall methotrexate are used to treat rheumatoid arthritis. Plaquenil is also used to treat or prevent malaria, and to treat symptoms of discoid or systemic lupus erythematosus. Rheumatrex and Trexall are also used to treat some cancers and severe skin diseases such as severe psoriasis. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs.