Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Metabolism of chloroquine Chloroquine for restless leg syndrome Plaquenil treatment lyme disease Plaquenil and Headache - from FDA reports Summary Headache is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take medication Enbrel, and have Pain. Thanks for your advice, Shani. The headaches were just bad headaches and stopped when I started taking Plaquenil at night instead of the morning. The blurred vision came separately and went a day or two after I stopped the Plaquenil again. As it happens, my GP phoned me today about something else and I told her about this. Feeling that others can hear your thoughts feeling, seeing, or hearing things that are not there fever with or without chills general feeling of tiredness or weakness headache inability to move the eyes increased blinking or spasms of the eyelid joint or muscle pain Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Can plaquenil cause headaches Plaquenil migraines - Autoimmune diseases - Inspire, Plaquenil headache. Lupus Forums at The Lupus Site Chloroquine resistant malaria in pregnantPlaquenil lower seizure thresholdWhat are the side effects of plaquenilPlaquenil standard of care optometry Maybe, he can give you something to help with the headaches. Also, Plaquenil can take up to 6 months before you really start to see improvement from the drug. If you have any more questions please feel free to ask away and I hope that you can get your headaches under control. Plaquenil and weight gain -. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. When I started Plaquenil back in November last year, I had terrible headaches which started about 1/2 an hour after taking pills. It happened so consistently that I started taking tylenol when I would take it. I would lay down with an ice pack under my neck and darken the room. After about 30min of resting with the ice pack. According to the Mayo Clinic and New Zealand Dermatological Society, Plaquenil, given long term for diseases such as RA, can cause brain and nerve diseases such as headaches, dizziness, muscle weakness and seizures. Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects. diarrhea. dizziness. hair loss. headache. increased skin sensitivity to sunlight. loss of appetite.