Canine uveodermatologic syndrome (Vogt-Koyanagi-Harada-like syndrome) is a syndrome of concurrent granulomatous uveitis and depigmenting dermatitis reported most commonly in the Akita, Samoyed, and Siberian husky. The cause of the disease unknown but in man a cell-mediated hypersensitivity to melanin and melanocytes in conjunction with the production of antibodies against melanin, gangliosides, and photoreceptors has been shown. Melanocytes in the uveal tract, inner ear, leptomeninges and skin are all affected. The syndrome is characterized by an acute onset of uveitis. Subsequent symmetrical depigmentation of the nose, lips, eyelids, and other pigmented areas begins within 10 days to several months. Histopathologic changes consist of a histiocytic interface dermatitis. Aggressive management of the uveitis is necessary to prevent posterior synechia, secondary glaucoma, cataracts, and loss of vision. Systemic glucocorticoids plus another immunosuppressive drug such as azathioprine are needed to treat both the ocular and cutaneous disease. Affected dogs begin to lose hair from the pinnae about 6 to 9 months of age and the hair loss progresses slowly to complete pinnal alopecia. In the second syndrome, dogs gradually begin to lose hair in the postauricular regions, on the ventral neck, over the entire ventrum, and on the caudomedial thighs. Pattern alopecia (or pattern baldness) is most commonly seen in small, shorthaired breeds of dogs such as dachshunds, Manchester Terriers, Miniature Pinschers, and Chihuahuas. The condition begins at about 6 months of age and is more commonly recognized in females. Reno Sparks Cab Company was founded in 1979 by Owner and President Roy L. RSCC began as a small operation, which has grown over the years to be the largest taxi company in Northern Nevada. 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Clonidine, sold as the brand name Catapres among others, is a medication used to treat high blood pressure, attention deficit hyperactivity disorder, drug withdrawal alcohol, opioids, or smoking, menopausal flushing, diarrhea, and certain pain conditions. Fentanyl also spelled fentanil is an opioid used as a pain medication and together with other medications for anesthesia. Fentanyl is also made illegally and used as a recreational drug, often mixed with heroin or cocaine. References. Australian Medicines Handbook. Clonidine anaesthesia. In Australian. Medicines Handbook Internet. Adelaide South Australia Australian.