Emily Yoffe: Good afternoon, I look forward to your questions. I’ve always been completely open and careful with partners and, to my knowledge, have not passed it along to anyone. I’ve worked through the initial feelings of having an STD years ago and have lived very comfortably since then. As a result, I got herpes the moment I lost my virginity. STD Meds: to Take or Not to Take: The guy I lost my virginity to (about 20 years ago) was not as forthcoming about certain things as my naive teenage self expected him to be. The only times I’ve ever taken medication for it were when I was younger, the outbreaks were more frequent and more severe, and I was still learning how to manage my health and be aware of my body. Now I only have one or two mild outbreaks a year, if that. I’ve never been on suppressive therapy until recently, at the urging of the guy I’m currently seeing. Yesterday May 14 at the irrepressible Holiday Inn in historic (3 strip store malls & a Holiday Inn) Gaithersburg, Maryland the FDA Anitiviral Drug Advisory Committee met for the second time in two days, this time to consider approval of Glaxo Smith Kline's Valtrex (aka Valcyclovir) for use "to reduce the risk of transmission of genital herpes with the use of suppressive therapy and safer sex practices at the dose of 500 mg once daily". The Committee voted 11-0 unanimously to recommend approval to the FDA. GSK conducted an 8 month international study for this approval and the study showed that using 500 mg of Valtrex once daily resulted in a 75% reduction in transmission of symptomatic genital herpes infection, and also showed a 48% reduction in the acquisition asymptomatic acquisition of herpes-2 documented by HSV-2 seroconversion during the study. 4 of 743 (0.5%) study participants who received Valcyclovir (Valtrex) developed symptomatic HSV-2 acquisition compared to 16 of 741 (2.2%) study participants who received placebo in the study (p-value: 0.007). Acquisition of asymptomatic HSV-2 occurred in 14 of 743 (1.9%) persons receiving Valtrex 500 mg once daily compared to 27 of 741 (3.6%) persons receiving placebo who acquired asymptomatic HSV-2 (p-value: 0.038). Men were less likely in the study to develop symptomatic genital herpes: 4.1% of females receiving placebo vs 1.2% of men; 0.8% of females receiving Valtrex vs 0.4% of men receiving Valtrex. Having HSV-1 may provide a protective effect from developing symptomatic genital herpes. For study participants receiving placebo having HSV-1 did not reduce the risk for transmission, 2.2% of persons who were HSV-1 negative vs 2.1% of persons who were HSV-1 positive developed symptomatic genital herpes. But for persons receiving Valtrex 0.9% of persons who were HSV-1 negative developed symptomatic genital herpes compared to 0.4% of persons who were HSV-1 positive. Levitra libido Prednisone risks Once-daily suppressive therapy with valacyclovir significantly reduces the risk of transmission of genital herpes among heterosexual, HSV-2–discordant couples. Dec 19, 2018. Valtrex can treat cold sores, recurrent infections caused by the herpes. Suppressive therapy, which means taking medication every day to. Currently, Valtrex is approved for several types of use 1 treatment of initial genital herpes 1000 mg twice daily for 10 days 2 treatment of recurrent genital herpes 500 mg twice daily for 3 days 3 chronic suppressive treatment of recurrent genital herpes 1000 mg once daily or 500 mg once daily alternate dose I also see patients who suffer through multiple terrible outbreaks of herpes who have NEVER HEARD of suppressive therapy! If you have more than six outbreaks a year, you should definitely consider suppressive therapy to reduce the number, duration and severity of herpes attacks. Here's a list of questions to ask your doctor about suppressive therapy to see if it is right for you. Studies show that appropriately dosed suppressive therapy can reduce herpes attacks by 70-80%! Many people who take daily antiviral therapy have NO outbreaks at all. Thus many people with genital herpes who have fewer than 6 outbreaks a year may also want to consider daily therapy... particularly if those outbreaks interfere with the quality of your life. Given that daily suppressive therapy can reduce (see next question) the transmission of the virus, I offer it to most of my patients who have outbreaks more than once a year. Can I still transmit herpes while on suppressive therapy? There aren't a lot of studies looking at asymptomatic shedding of herpes while on suppressive therapy. I've seen all sorts of oddball regimens that patients are taking. But what has been done so far show that while daily antiviral therapy for a year significantly decreases asymptomatic shedding of virus, it doesn't eliminate it. And in these tough economic times, patients often are taking shortcuts with their meds! Several medications, including Valtrex, are available to treat cold sores. Some are used topically (on the skin) and others are used orally (by mouth), but the goal is to treat cold sores as early as possible. That's because starting a medication when prodromal symptoms such as burning, tingling, or redness begin will give a person with a cold sore the best chance of either preventing an actual blister from forming or shortening a blister's course once it does appear. While the FDA has approved the use of certain drugs for cold sores, some antiviral drugs aren't specifically FDA-approved for cold sores but have been shown in clinical studies to be effective treatments. Given this, receiving a prescription for an off-label use of one of these drugs may help eliminate or prevent cold sores. Antiviral drugs can have several effects on oral herpes simplex viral infections, including cold sores. These medications can decrease the time that it takes for cold sores to heal and reduce symptoms, especially pain. Valtrex suppressive Valtrex and Other Antivirals That Treat Cold Sores, Valtrex and Other Antivirals That Treat Cold Sores - Verywell Health Prednisone liver Mar 22, 2010. Do you recommend low-dose suppressive antiviral therapy. A recent review on antiviral resistance to acyclovir, valacyclovir, and famciclovir. Chronic suppressive antiviral therapy for herpes labialis - Clinical.. Valtrex For Reducing Transmission of Genital Herpes- FDA.. Valtrex Valacyclovir HCL Effectiveness - Price-RX. How Much Valacyclovir Valtrex Should You Take During a Herpes Outbreak? Have you noticed the warning signs of a herpes outbreak starting t. March 25, 2003 San Francisco — Final analysis of a multicenter study of 1,484 herpes simplex virus 2 HSV-2–discordant couples indicates that chronic valacyclovir suppressive therapy can. The psychological morbidity. Oral acyclovir, valacyclovir or famciclovir are recommended for routine use. Longrterm suppressive therapy is effective in reducing.