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    Metformin (brand names Glucophage, Glucophage XR, Fortamet, Riomet, Glumetza, and others) is a popular and highly effective oral diabetes drug used to help manage Type 2 diabetes. This drug works by lowering the amount of glucose made by the liver and by making the body’s cells more sensitive to insulin. Metformin also has some other beneficial effects in that it may help lower blood lipid, or fat, levels (cholesterol and triglycerides) and can, in some people, promote a small amount of weight loss. Metformin can be used with other diabetes pills and with insulin. Side effects of taking metformin are relatively rare, the most common being bloating, nausea, and diarrhea, all of which are temporary. Some people shouldn’t take metformin, including people with kidney disease, liver disease, or congestive heart failure, for example, because of an increased risk of a potentially fatal condition called lactic acidosis. In recent years, there’s been some concern over the risk of vitamin B12 deficiency in people who take metformin. So many women with PCOS are prescribed Metformin (an insulin-sensitizing drug) to manage their Polycystic Ovarian Syndrome. Metformin has been shown to improve many aspects of PCOS, including weight loss, fertility and improved testosterone levels (1). But, it also leads to Vitamin B12 deficiency if used at high doses or for long periods of time. So, here’s what you need to know about Metformin and Vitamin B12 deficiency with PCOS. As I have already mentioned, Metformin is an insulin sensitizing drug that is often prescribed for women with PCOS. It works by decreasing absorption of glucose through the intestines, lowering the amount of glucose produced by the liver and making the body more sensitive to the insulin that is being produced. The overall effect of Metformin use for PCOS is lowered testosterone levels, improved ovulation and fertility as well as a more regular menstrual cycle. Well, it is good although there are some nasty side effects. A full discussion on Metformin is not going to be dealt with now, though.

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    Cocklety How Byre is part of Cocklety How, a 17th century converted barn that sits at the foot of Catbells, overlooking the fields, woods and fells of the Borrowdale valley. The Byre extension was built in 2000 to the highest possible standards. The result is a beautiful cottage that sympathetically blends the original stonework and beams of the old byre with a modern vaulted ceiling extension that curves along the contour of the fellside to make the most of the spectacular views. The cottage is extremely spacious and the fixtures and fitting are of a very high quality, with La-Z-Boy leather arm chairs, solid oak floors and a sound system. Luxury cottage suitable for up to 2/3 guests (sofa bed for third guest or for 2 guests requiring a twin). Can be booked with Cocklety How Stable Loft and/or Cocklety How Studio – plenty of space for socialising. Great off-peak rates – the perfect cottage for ‘staying in’ on rainy days! For guests who would prefer not to clean The Byre at the end of their stay we offer an optional end of stay cleaning serivce. For £60 we will waive the conditions of occupancy in clause 6 that state you must leave the cottage as you found it ready for the next guests. The most common side-effects are feeling sick, diarrhoea and tummy (abdominal) pain. These symptoms usually pass after the first few days of treatment. Keep your regular appointments with your doctor and clinics. Insulin is a hormone which is made naturally in your body, in the pancreas. It helps to control the levels of sugar (glucose) in your blood. If your body does not make enough insulin, or if it does not use the insulin it makes effectively, this results in the condition called sugar diabetes (diabetes mellitus). People with diabetes need treatment to control the amount of sugar in their blood. This is because good control of blood sugar levels reduces the risk of complications later on.

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